3 documents found, page 1 of 1
Exosomes and STUB1/CHIP cooperate to maintain intracellular proteostasis
Ferreira, João Vasco; Soares, Ana Rosa; Ramalho, José S.; Ribeiro-Rodrigues, Teresa; Máximo, Catarina; Zuzarte, Mónica; Girão, Henrique; Pereira, PauloDeregulation of proteostasis is a main feature of many age-related diseases, often leading to the accumulation of toxic oligomers and insoluble protein aggregates that accumulate intracellularly or in the extracellular space. To understand the mechanisms whereby toxic or otherwise unwanted proteins are secreted to the extracellular space, we inactivated the quality-control and proteostasis regulator ubiquitin l...
Trait determinants of impulsive behavior: a comprehensive analysis of 188 rats
Soares, Ana Rosa; Esteves, Madalena; Moreira, Pedro Miguel Silva; Cunha, Ana Margarida; Guimarães, Marco Rafael Machado; Carvalho, Miguel MurteiraImpulsivity is a naturally occurring behavior that, when accentuated, can be found in a variety of neuropsychiatric disorders. The expression of trait impulsivity has been shown to change with a variety of factors, such as age and sex, but the existing literature does not reflect widespread consensus regarding the influence of modulating effects. We designed the present study to investigate, in a cohort of sign...
Análise da estrutura física de serviços de alimentação localizados na Zona Sul ...
Soares, Ana RosaSubmitted by Fernando Vieira (nandogusto6@gmail.com) on 2015-07-06T13:53:56Z No. of bitstreams: 1 ARS22062015.pdf: 1262237 bytes, checksum: 7f811d6979bcbefdbb1f3dc1295ffc5b (MD5); Made available in DSpace on 2015-07-06T13:53:57Z (GMT). No. of bitstreams: 1 ARS22062015.pdf: 1262237 bytes, checksum: 7f811d6979bcbefdbb1f3dc1295ffc5b (MD5); Os colaboradores dos serviços de alimentação devem estar ergonomicamente aj...