5 documents found, page 1 of 1
Acute MDPV Binge Paradigm on Mice Emotional Behavior and Glial Signature
Campeão, Mafalda; Fernandes, Luciana; Pita, Inês R.; Lemos, Cristina; Ali, Syed F.; Carvalho, Félix; Rodrigues-Santos, Paulo; Ribeiro, Carlos A. Fontes3,4-Methylenedioxypyrovalerone (MDPV), a widely available synthetic cathinone, is a popular substitute for classical controlled drugs of abuse, such as methamphetamine (METH). Although MDPV poses public health risks, its neuropharmacological profile remains poorly explored. This study aimed to provide evidence on that direction. Accordingly, C57BL/6J mice were exposed to a binge MDPV or METH regimen (four intra...
Chitosan Nanoparticles: Shedding Light on Immunotoxicity and Hemocompatibility
Jesus, Sandra; Marques, Ana Patrícia; Duarte, Alana; Soares, Edna; Costa, João Panão da; Colaço, Mariana; Schmutz, Mélanie; Som, ClaudiaNanoparticles (NPs) assumed an important role in the area of drug delivery. Despite the number of studies including NPs are growing over the last years, their side effects on the immune system are often ignored or omitted. One of the most studied polymers in the nano based drug delivery system field is chitosan (Chit). In the scientific literature, although the physicochemical properties [molecular weight (MW) ...
Early cardiac changes in a rat model of prediabetes: brain natriuretic peptide ...
Nunes, Sara; Soares, Edna; Fernandes, João; Viana, Sofia D.; Carvalho, Eugenia; Pereira, Frederico C.; Reis, FlávioBackground: Diabetic cardiomyopathy (DCM) is defined as structural and functional changes in the myocardium due to metabolic and cellular abnormalities induced by diabetes mellitus (DM). The impact of prediabetic conditions on the cardiac tissue remains to be elucidated. The goal of this study was to elucidate whether cardiac dysfunction is already present in a state of prediabetes, in the presence of insulin r...
The role of inflammation in diabetic cardiomyopathy
Reis, Flávio; Nunes, Sara; Soares, Edna; Pereira, FredericoType 2 diabetes mellitus (T2DM) is a major risk factor for developing cardiovascular disease and represents a serious public health problem, with high rates of mortality and morbidity worldwide. T2DM etiology is complex and multifactorial and is associated with several complications, including those at myocardium level. Diabetic cardiomyopathy (DCM) is viewed as a specific cardiomyopathy and defined as structur...
Diabetic encephalopathy: the role of oxidative stress and inflammation in type ...
Reis, Flávio; Soares, Edna; Nunes, Sara; Pereira, Frederico C.Type 2 diabetes mellitus (T2DM) is a heterogeneous metabolic disorder associated with an increased risk for central nervous system disorders. Diabetic encephalopathy is a relatively unknown diabetes complication, characterized by electrophysiological, structural, neurochemical, and degenerative neuronal changes that lead to cognitive functioning limitations. Besides chronic hyperglycemia and dyslipidemia, diabe...