Funding Information: Work was supported by project funding from Fundação para a Ciência e para a Tecnologia (FCT) ( PTDC/MED-FAR/30933/2017 and PTDC/MED-FAR/4834/2021 ) and by H2020-WIDESPREAD-05-2017-Twinning (EpiEpinet) under grant agreement No. 952455 . MF-F ( SFRH/BD/147505/2019 ), NR ( PD/BD/113463/2015 ), JF-G ( PD/BD/114441/2016 ) and CM-L ( SFRH/BD/118238/2016 ) are supported by PhD fellowships from FCT...