87 documents found, page 1 of 9

The essential integration of sex and gender in immunological research

Funding Information: The Study Group \u201CImmune Sex Differences\u201D acknowledges support from the European Federation of Immunological Societies (EFIS) for its activities. EFIS assisted in disseminating the position letter to the immunology community for endorsement but had no role in the conception, drafting, or approval of its content.

Tubulin acetylation and the cellular mechanosensing and stress response

Microtubule (MT) acetylation has emerged as a critical regulator of cellular stress responses, integrating mechanical and oxidative stimuli to support cellular adaptability and survival. This post-translational modification (PTM) enhances MT flexibility and resilience, enabling cells to withstand mechanical challenges such as changes in extracellular matrix stiffness and applied forces. Through its impact on MT...

Tubulin acetylation: a critical regulator of microtubule function

The cytoskeleton is conserved throughout the eukaryotic lineage and consists of a complex dynamic network mainly composed of three distinct polymers: microtubules (MTs), actin filaments, and intermediate filaments. MTs are polymers of α/β-tubulin heterodimers, playing a myriad of distinct cellular functions, and are the main components of complex structures like the mitotic spindle, cilia, and centrioles. Post-...

Desvendando o segredo das rochas: uma viagem pelos núcleos de arte rupestre da ...

A Arte Rupestre da Idade do Ferro do Vale do Côa (Portugal): micro espaços dent...

Balancing act: tubulin glutamylation and microtubule dynamics in Toxoplasma gondii

The success of the intracellular parasite Toxoplasma gondii in invading host cells relies on the apical complex, a specialized microtubule cytoskeleton structure associated with secretory organelles. The T. gondii genome encodes three isoforms of both α- and β-tubulin, which undergo specific post-translational modifications (PTMs), altering the biochemical and biophysical proprieties of microtubules and modulat...

Balancing act: tubulin glutamylation and microtubule dynamics in Toxoplasma gondii

The success of Toxoplasma gondii (intracellular parasite) host cell invasion relies on the apical complex, a specialized microtubule cytoskeleton structure associated with secretory organelles. The genome encodes three isoforms of both α- and β-tubulin which are altered by specific post-translational modifications (PTMs), changing the biochemical/biophysical proprieties of microtubules, and modulating their int...

Immunophenotyping of palatine tonsils in children with OSAS versus recurrent to...

Introduction - Obstructive Sleep Apnea Syndrome (OSAS) and Recurrent Tonsillitis (RA) are the main indications for performing tonsillectomy in children. Despite the growing knowledge in tissue immunology of palatine tonsils, the pathophysiology that leads to the development of OSAS or RA is not fully known. Objectives - Comparative immunophenotypic analysis of children with OSAS versus RA. The epidemiological s...

The nuclear levels of thioredoxin reductase 1, gamma-H2AX, and yap are modulate...

Diabetes is a condition characterized by impaired regulation of blood glucose levels, leading to various complications such as hypertension, cardiovascular disease, and retinopathy. Diabetic retinopathy (DR), caused by a disrupted retinal blood barrier, is associated with oxidative stress resulting from dysregulated glucose levels in the retina. The primary cilium, an organelle involved in energy balance and gl...

Os cílios primários regulam os níveis de tiorredoxina redutase 1 e de yH2AX em ...

A diabetes caracteriza-se por uma anormal capacidade de controlar o nível de glucose na corrente sanguínea, podendo levar a outras complicações, tais como hipertensão, doenças cardiovasculares, e retinopatia. A desregulação dos níveis de glucose na retina tem demonstrado aumentar os níveis de peróxido de hidrogénio, conduzindo a uma rutura na barreira sanguínea da retina, uma das causas de retinopatia diabética...