7 documents found, page 1 of 1
Patterns of Default Mode Network Deactivation in Obsessive Compulsive Disorder
Gonçalves, ÓF; Soares, JM; Carvalho, S; Leite, J; Ganho-Ávila, A; Fernandes-Gonçalves, A; Pocinho, F; Carracedo, A; Sampaio, AThe objective of the present study was to research the patterns of Default Mode Network (DMN) deactivation in Obsessive Compulsive Disorder (OCD) in the transition between a resting and a non-rest emotional condition. Twenty-seven participants, 15 diagnosed with OCD and 12 healthy controls (HC), underwent a functional neuroimaging paradigm in which DMN brain activation in a resting condition was contrasted with...
The Bounds Of Education In The Human Brain Connectome
Marques, P; Soares, JM; Magalhães, R; Santos, NC; Sousa, NInter-individual heterogeneity is evident in aging; education level is known to contribute for this heterogeneity. Using a cross-sectional study design and network inference applied to resting-state fMRI data, we show that aging was associated with decreased functional connectivity in a large cortical network. On the other hand, education level, as measured by years of formal education, produced an opposite eff...
Brain structure across the lifespan: the influence of stress and mood
Soares, JM; Marques, P; Magalhães, R; Santos, NC; Sousa, NNormal brain aging is an inevitable and heterogeneous process characterized by a selective pattern of structural changes. Such heterogeneity arises as a consequence of cumulative effects over the lifespan, including stress and mood effects, which drive different micro- and macro-structural alterations in the brain. Investigating these differences in healthy age-related changes is a major challenge for the compr...
Cerebral and cerebellar MRI volumes in Williams syndrome
Osório, A; Soares, JM; Prieto, MF; Vasconcelos, C; Fernandes, C; Sousa, SB; Carracedo, A; Gonçalves, OF; Sampaio, AIndividuals with Williams syndrome (WS) present a set of cognitive, affective and motor symptoms that resemble those of patients with lesions to the cerebellum. Although there is some evidence for overall structural alterations in this brain region in WS, explorations on cerebellar white matter and cerebellar cortex volumes remain rather neglected. We aimed to compare absolute and relative cerebellar volumes, a...
Brain activation of the defensive and appetitive survival systems in obsessive ...
Gonçalves, OF; Soares, JM; Carvalho, S; Leite, J; Ganho, A; Fernandes-Gonçalves, A; Frank, B; Pocinho, F; Relvas, J; Carracedo, A; Sampaio, ASeveral studies have shown that basic emotions are responsible for a significant enhancement of early visual processes and increased activation in visual processing brain regions. It may be possible that the cognitive uncertainty and repeated behavioral checking evident in Obsessive Compulsive Disorder (OCD) is due to the existence of abnormalities in basic survival circuits, particularly those associated with ...
Plasticity of resting state brain networks in recovery from stress
Soares, JM; Sampaio, A; Marques, P; Ferreira, LM; Santos, NC; Marques, F; Palha, JA; Cerqueira, JJ; Sousa, NChronic stress has been widely reported to have deleterious impact in multiple biological systems. Specifically, structural and functional remodeling of several brain regions following prolonged stress exposure have been described; importantly, some of these changes are eventually reversible. Recently, we showed the impact of stress on resting state networks (RSNs), but nothing is known about the plasticity of ...
Stress Impact on Resting State Brain Networks
Soares, JM; Sampaio, A; Ferreira, LM; Santos, NC; Marques, PS; Marques, F; Palha, JA; Cerqueira, JJ; Sousa, NResting state brain networks (RSNs) are spatially distributed large-scale networks, evidenced by resting state functional magnetic resonance imaging (fMRI) studies. Importantly, RSNs are implicated in several relevant brain functions and present abnormal functional patterns in many neuropsychiatric disorders, for which stress exposure is an established risk factor. Yet, so far, little is known about the effect ...