The stem bark of Simarouba amara Aubl., Simaroubaceae, is widely used in Brazilian folk medicine and in many countries of Central and South America for the treatment of malaria, intestinal parasites, diarrhea, anemia and fever. Although quassinoids are considered chemotaxonomic markers of the species, the unavailability of commercialization standards stay as a challenge for its quality control. Therefore, the p...