2 documents found, page 1 of 1
Synthesis and structure-activity relationships of new chiral spiro-β-lactams hi...
Alves, Nuno Guerreiro; Bártolo, Inês; Alves, Américo J.S.; Fontinha, Diana; Francisco, Denise; Lopes, Susana M.M.; Soares, Maria I.L.The synthesis and antimicrobial activity of new spiro-β-lactams is reported. The design of the new molecules was based on the structural modulation of two previously identified lead spiro-penicillanates with dual activity against HIV and Plasmodium. The spiro-β-lactams synthesized were assayed for their in vitro activity against HIV-1, providing relevant structure-activity relationship information. Among the te...
Cholesteryl hemiesters alter lysosome structure and function and induce proinfl...
Domingues, Neuza; Estronca, Luís M.B.B.; Silva, João; Encarnação, Marisa R.; Mateus, Rita; Silva, Diogo Pinto Lobo Jesus; Santarino, Inês B.Rationale: Cholesteryl hemiesters are oxidation products of polyunsaturated fatty acid esters of cholesterol. Their oxo-ester precursors have been identified as important components of the "core aldehydes" of human atheromata and in oxidized lipoproteins (Ox-LDL). We had previously shown, for the first time, that a single compound of this family, cholesteryl hemisuccinate (ChS), is sufficient to cause irreversi...