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Unravelling the para- and ortho-benzene substituent effect on the glass transit...

Zaidi, Sami; Soares, Maria J.; Bougarech, Abdelkader; Thiyagarajan, Shanmugam; Guigo, Nathanael; Abid, Souhir; Abid, Majdi; Silvestre, Armando J.D.

High-glass transition thermoplastic polymers have dawned much attention in recent years due to their typical stiffness, enhanced thermal properties, and more importantly the emerging need to replace commercial fossil-based products by more sustainable alternatives, derived from renewable resources. In this regard we engineer here for the first time the design of wholly (hetero-)aromatic polyesters based on a ke...


Affective state dependence and relative trait stability of perfectionism in sle...

Maia, Berta R.; Soares, Maria J.; Pereira, Ana T.; Marques, Mariana; Bos, Sandra C.; Gomes, Ana; Valente, José; Azevedo, Maria Helena; Macedo, António

Objective: To evaluate the degree of absolute change, relative stability and state dependence of trait perfectionism in sleep disturbances in a sample of university students. Method: Participants completed the Multidimensional Perfectionism Scale and two items concerning sleep difficulties. The mean age at T0 (baseline) was 19.59 years (SD = 1.61, range = 17-25) and 62.5% of the sample were female. Results: Abs...


Perfectionism in obsessive-compulsive and eating disorders

Maia, Berta R.; Soares, Maria J.; Gomes, Ana; Marques, Mariana; Pereira, Ana Telma; Cabral, Ana Sofia; Valente, José; Bos, Sandra C.; Pato, Michele

Objective: The main aims of this article are twofold. First, to assess perfectionism dimensions in obsessive-compulsive disorder and eating disorders in comparison with psychiatric control (depression/anxiety) and non-clinical control groups. Second, to examine if perfectionism is specifically related to these different clinical conditions. Method: Thirty-nine outpatients with obsessive-compulsive disorder, 24 ...


Transthyretin: No association between serum levels or gene variants and schizop...

Ruano, Dina; Macedo, António; Soares, Maria J.; Valente, José; Azevedo, Maria H.; Hutz, Mara H.; Gama, Clarissa S.; Lobato, Maria I.

It has been proposed that schizophrenia results from an environmental insult in genetically predisposed individuals. Environmental factors capable of modulating transcriptional activity and their carriers could link the genetic and environmental components of schizophrenia. Among these is transthyretin (TTR), a major carrier of thyroid hormones and retinol-binding protein (RBP). Retinoids and thyroid hormones r...


Transthyretin: no association between serum levels or gene variants and schizop...

Ruano, Dina; Macedo, António; Soares, Maria J.; Valente, José; Azevedo, Maria H.; Hutz, Mara H.; Gama, Clarissa S.; Lobato, Maria I.

It has been proposed that schizophrenia results from an environmental insult in genetically predisposed individuals. Environmental factors capable of modulating transcriptional activity and their carriers could link the genetic and environmental components of schizophrenia. Among these is transthyretin (TTR), a major carrier of thyroid hormones and retinol-binding protein (RBP). Retinoids and thyroid hormones r...


No evidence of association or linkage disequilibrium between polymorphisms in t...

Ambrósio, Alda M.; Kennedy, James L.; Macciardi, Fabio; Barr, Cathy; Soares, Maria J.; Oliveira, Catarina R.; Pato, Carlos N.

Alterations in dopaminergic system have been implicated in the pathophysiology of this disease for many years, and this study was performed to assess the possible involvement of the dopamine D4 receptor (DRD4) gene polymorphisms either in the 5prime upstream or in the coding regions, in the etiology of schizophrenia. The approach included an association study with 90 Portuguese trios by doing the analysis of th...


Lack of association or linkage disequilibrium between schizophrenia and polymor...

Ambrósio, Alda M.; Kennedy, James L.; Macciardi, Fabio; Coelho, Isabel; Soares, Maria J.; Oliveira, Catarina R.; Pato, Carlos N.

Genetic factors play a major role in the etiology of schizophrenia and disturbances of serotonergic pathways have been implicated in this disorder. The aim of the present study was to examine genetic association between schizophrenia and polymorphisms in the 5-HT1Dalpha (TaqI) and 5-HT1Dbeta (T261G and G861C) autoreceptor genes in ninety trios from Portugal. No association or linkage disequilibrium was obtained...


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