92 documents found, page 1 of 10
Cyto-Histological Profile of MicroRNAs as Diagnostic Biomarkers in Differentiat...
Matos, ML; Pinto, M; Alves, M; Canberk, S; Gonçalves, A; Bugalho, MJ; Papoila, AL; Soares, PIntroduction: The repertoire of microRNAs (miRNAs) in thyroid carcinomas starts to be elucidated. Among differentiated thyroid carcinomas (DTCs), papillary thyroid carcinoma (PTC) is the most frequent. The assessment of miRNAs expression may contribute to refine the pre-surgical diagnosis in order to obtain a personalized and more effective treatment for patients. Aims: This study aims to evaluate (1) the miRNA...
Weight loss in patients with severe obesity after bariatric surgery–the potenti...
Rodrigues, J; Magalhães, V; Santos, MP; Reis, C; Pichel, F; Soares, P; Santos, J; Vilela, SBackground: Despite the potential effectiveness of bariatric surgery in promoting weight loss, a considerable proportion of patients still face the challenge of achieving optimal post-surgery outcomes. The timing of eating, in addition to the content of what is eaten, as well as chronotype and social jetlag (a marker of circadian misalignment), have been implicated in weight regulation. However, the current und...
3PC-024Implementation of a strategy to overcome the potential toxic effects of ...
Barbosa, R; Fraga, S; Soares, P; Fernandez-Llimos, F; Baltazar, F; Barbosa, C.M.
Adapting to COVID-19: Insights from Portuguese residents' home-based life
Aguiar, A; Soares, P; Barbosa, P; Duarte, R; Pinto, MBACKGROUND: The COVID-19 pandemic led to widespread lockdowns and remote work and educational practices that have impacted the lives of many families. OBJECTIVE: We aimed to investigate how parents and caregivers altered their routines due to online schooling and teleworking, exploring their association with increased anxiety and depression symptoms. METHODS: We conducted an online cross-sectional study and col...
LOCUS (LOng Covid–Understanding Symptoms, events and use of services in Portuga...
Dinis Teixeira, JP; Santos, MJ; Soares, P; Azevedo, L; Barbosa, P; Vilas-Boas, A; Cordeiro, JV; Dias, S; Fonseca, M; Goes, AR; Lobão, MJ; Moniz, MApproximately 10% of patients experience symptoms of Post COVID-19 Condition (PCC) after a SARS-CoV-2 infection. Akin acute COVID-19, PCC may impact a multitude of organs and systems, such as the cardiovascular, respiratory, musculoskeletal, and neurological systems. The frequency and associated risk factors of PCC are still unclear among both community and hospital settings in individuals with a history of COV...
3PC-030Evaluation of excipients used in paediatric compounded formulations pres...
Barbosa, R; Fraga, S; Sampaio, C; Sousa, L; Soares, P; Barbosa, C.M.
Evaluating Data Sharing of SARS-CoV-2 Genomes for Molecular Epidemiology across...
Rito, T; Fernandes, P; Duarte, R; Soares, PFollowing the emergence of COVID-19 in December 2019, caused by the coronavirus SARS-CoV-2, the disease spread dramatically worldwide. The use of genomics to trace the dissemination of the virus and the identification of novel variants was essential in defining measures for containing the disease. We aim to evaluate the global effort to genomically characterize the circulating lineages of SARS-CoV-2, considerin...
Ecological factors associated with areas of high tuberculosis diagnosis delay
Soares, P; Aguiar, A; Leite, A; Duarte, R; Nunes, CObjective: We aimed to identify areas of high tuberculosis (TB) diagnosis delay in mainland Portugal in 2017 and ecological factors associated with these areas. Study design: This was an ecological study. Methods: We considered all notified pulmonary TB cases from the Portuguese National Tuberculosis Surveillance System in mainland Portugal. Diagnostic delays were calculated at the municipality level. Demograph...
A Case-Control Study of Contextual Factors for SARS-CoV-2 Transmission
Leite, A; Leão, T; Soares, P; Severo, M; Moniz, M; Lucas, R; Aguiar, P; Meireles, P; Lunet, N; Nunes, C; Barros, HBackground: Knowledge on the settings and activities associated with a higher risk of SARS-CoV-2 transmission is essential to inform decision-making. We thus designed a case-control study to identify relevant settings for community transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Portugal. Methods: We evaluated 1,088 cases, identified through the national surveillance system, and ...
The role of c-Met and VEGFR2 in glioblastoma resistance to bevacizumab
Carvalho, B; Lopes, JM; Silva, R; Peixoto, J; Leitão, D; Soares, P; Fernandes, AC; Linhares, P; Vaz, R; Lima, JDismal prognosis of glioblastoma (GBM) prompts for the identification of response predictors and therapeutic resistance mechanisms of current therapies. The authors investigated the impact of c-Met, HGF, VEGFR2 expression and microvessel density (MVD) in GBM patients submitted to second-line chemotherapy with bevacizumab. Immunohistochemical expression of c-Met, HGF, VEGFR2, and MVD was assessed in tumor specim...