103 documents found, page 1 of 11

Molecular profiling of prognostic biomarkers in Melanoma

Cutaneous melanoma (CM) is the most aggressive and deadliest form of skin cancer (1). Its development is influenced by the genetic background, genetic mutations and environmental factors. The three most frequent mutations of CM appear in BRAF gene, which leads to uncontrolled cell growth, in NRAS gene, that disrupts normal cell signaling, and in TERT promoter, that increases telomerase activity and play a cruci...

Study of the relevance of antioxidant enzymes in thyroid cancer

Thyroid cancer(TC) is the most common endocrine malignancy, arising from follicular and parafollicular cells. Oxidative stress, caused by excess reactive oxygen species(ROS) and metabolites, influences TC development and progression, as the thyroid is highly exposed to ROS. The redox balance is maintained by antioxidant enzymes (SOD, GPX) and non-enzymatic antioxidants, which limit ROS formation and detoxify me...

A decomposição de resíduos de abate de plantações florestais, dinâmica de liber...

Os resíduos de abate têm grande importância na fertilidade do solo, no sequestro de carbono no solo e na sustentabilidade produtiva das plantações florestais. Na região Mediterrânea (e.g. Portugal) considera-se que a carga combustível desses resíduos gera risco de incêndios, o que levou a incluir a sua gestão em instrumentos legislativos. Numa área florestal representativa, avaliou-se como a gestão desses resíd...

Plantas bioindicadoras. Emergencia primaveral con diferentes manejos del suelo

Apoyados en el concepto de que la distribución de las semillas es universal y que una semilla sólo germina cuando se crean las condiciones propicias para su germinación, se puede caracterizar el tipo de suelo a partir de la flora que está presente en él. A estas plantas que nos ayudan a conocer las características de un suelo se les llama “plantas bioindicadoras”. En una parcela de Sartaguda (Navarra) se dispus...

Unraveling the significance of DGCR8 and miRNAs in thyroid carcinoma

MicroRNAs (miRNAs) act as negative regulators for protein-coding gene expression impacting cell proliferation, differentiation, and survival. These miRNAs are frequently dysregulated in cancer and constitute classes of blood-based biomarkers useful for cancer detection and prognosis definition. In thyroid cancer (TC), the miRNA biogenesis pathway plays a pivotal role in thyroid gland formation, ensuring proper ...

Comparative Cyto-Histological Genetic Profile in a Series of Differentiated Thy...

Funding Information: This research received funding for SC, in the framework of a Ph.D. grant (SFRH/BD/147650/2019) supported by Portuguese funds through Fundação para a Ciência e a Tecnologia (FCT). This study is part of the project “Institute for Research and Innovation in Health Sciences” (UID/BIM/04293/2019) and the project “The Porto Comprehensive Cancer Center” ref. NORTE-01-0145-FEDER-072678—Consórcio PO...

A One pathology multicentre Portuguese approach to thyroid tumours of dogs and ...

Thyroid tumours are the most common endocrine tumours of dogs and cats. Feline thyroid tumours are essentially functional adenomas curable with thyroidectomy, whereas most canine thyroid tumours are non-functional carcinomas either unresectable or recurrent within two years in up 50%. The oncobiology of these tumours remains unclear, but investigating this aspect could contribute to the development of targeted ...

Natural regeneration of cork oak forests under climate change: a case study in ...

The sustainability of forest species is directly related to the success of stand regeneration. Assuring success is particularly critical in stands where perpetuity relies on natural regeneration, as is often the case with cork oak forests. However, 59% of the stand in Portugal have no natural regeneration, and climate change could further worsen the sustainability of the system. The study summarizes the factors...

Resin yield in species of Pinus spp. in mainland Portugal – first results

Significance of Furin Expression in Thyroid Neoplastic Transformation

Angiotensin-Converting Enzyme 2 (ACE2), Transmembrane Serine Protease 2 (TMPRSS2), and Furin were known to be key players in the SARS-CoV-2 infection, and the thyroid gland was revealed to be one of the relevant targets of the virus. Regardless of the viral infection, the expression of these molecules in the thyroid gland and their putative role in the neoplastic transformation of the thyrocytes has not been th...