93 documents found, page 1 of 10
Microvascular, biochemical, and clinical impact of hyperbaric oxygen therapy in...
Martins-Mendes, Daniela; Costa, Raquel; Rodrigues, Ilda; Camacho, Óscar; Coelho, Pedro Barata; Paixão-Dias, Vítor; Luís, Carla; Pereira, Ana CláudiaBackground: Diabetic foot ulcers (DFUs) are a serious complication of diabetes and are often difficult to treat. Hyperbaric oxygen therapy (HBOT) has been proposed as an adjunctive treatment to promote healing, but its long-term clinical and biological effects remain insufficiently characterized. This study aimed to evaluate the impact of HBOT on systemic biomarkers, local microvasculature, and clinical outcome...
Advancing diabetes treatment: from human beta cell technology to bioartificial ...
Sá, Joana; Sá, Simone; Leménager, Hélène; Costa, Raquel; Onteniente, Brigitte; Soares, Raquel; Ribeiro, Viviana P.; Oliveira, Ana L.In 2021, approximately 537 million people worldwide, primarily in low- and middle-income countries, were affected by diabetes, leading to approximately 6.7 million deaths annually or severe secondary complications including life-threatening hyperglycemia. For nearly 50 years, current therapeutic approaches include full pancreas transplantation and isolated pancreatic islets, more recently, cell therapy such as ...
A remodelação do fundo local na biblioteca pública: implementação das diretrize...
Soares, Raquel; Revez, Jorge, 1980-Na contemporaneidade globalizada, a preservação da identidade cultural tornou-se urgente, instigando as bibliotecas a ultrapassarem o seu papel tradicional. Este artigo explora a remodelação de fundos locais em bibliotecas públicas como estratégia para preservar o património cultural e promover a educação patrimonial. A pesquisa baseia-se numa abordagem mista que inclui questionários, revisão de literatura e um...
OPAC como Espaço de Curadoria Digital: Mediação Cultural e Alinhamento com os O...
Soares, RaquelA Biblioteca Municipal Fernando Piteira Santos utiliza o OPAC Koha como uma ferramenta ativa de curadoria digital e mediação cultural. Através de listas públicas temáticas, atualizadas mensalmente, promove-se o acesso qualificado ao acervo bibliográfico. Esta prática integra-se na comunicação institucional da biblioteca e reforça o seu papel educativo e participativo.
Development of a stable melanoma dual reporter cell line expressing Luciferase ...
Aguiar, Gonçalo; Torres, Sílvia; Prudêncio, Cristina; Soares, Raquel; Coelho, Pedro; Prudêncio, Cristina; Coelho, PedroMelanoma is the most aggressive and lethal form of skin cancer, with a high risk of metastatic spread. Obesity is recognized as a risk factor for various types of cancer. However, regarding melanoma, this association remains controversial. Obesity might act as a double-edged sword in melanoma, promoting primary tumour growth but at the same time limiting metastatic spread - the "obesity paradox”. Herein, we aim...
Vascular dysfunction in adipose tissue: Its impact on type 2 diabetes and cancer
Silva, Daniela Rosendo; Aguiar, Gonçalo; Luís, Carla; Soares, Raquel; Coelho, Pedro; Coelho, PedroThe overgrowth of adipose tissue is a major trigger for the development of other metabolic disorders, like insulin resistance, hypertension, type 2 diabetes, cardiovascular disease, and cancer. Among the causes of this association lies the fact that increased adiposity is accompanied by a nonfunctioning vascular component. Accordingly, vascular dysfunction within the adipose tissue is common in obesity and asso...
Type 2 Diabetes mellitus alters the cargo of (poly)phenol metabolome and the ox...
Reis, Ana; Rocha, Sara; Dias, Irundika HK.; Costa, Raquel; Soares, Raquel; Sánchez-Quesada, José Luis; Perez, Antonio; Freitas, Victor deThe incidence of diabetes on the worldwide population has tripled in the past 5 decades. While drug-based therapies are valuable strategies to treat and ease the socio-economic burden of diabetes, nutritional strategies offer valuable alternatives to prevent and manage diabetes onset and contribute to the sustainability of health budgets. Whilst, intervention studies have shown that (poly)phenol-rich diets impr...
A retrospective study in tumour characteristics and clinical outcomes of overwe...
Luís, Carla; Dias, João; Firmino‑Machado, João; Fernandes, Rute; Pereira, Deolinda; Baylina, Pilar; Fernandes, Rúben; Soares, RaquelObesity and breast cancer are two major pathologies closely associated with increasing incidence and mortality rates, especially amongst women. The association between both diseases have been thoroughly discussed but much is still to uncover. The aim of this study is to analyse tumour characteristics and clinical outcomes of overweight and obese women to disclosure potential associations and better understand t...
Bilateral breast cancer and the influence of body mass index in clinicopatholog...
Luís, Carla; Fernandes, Rute; Dias, João; Pereira, Deolinda; Firmino-Machado, João; Baylina, Pilar; Fernandes, Rúben; Soares, RaquelBreast cancer (BC) and obesity are two closely associated pathologies with increasing incidence and mortality rates. Bilateral Breast Cancer (BBC) displays a low incidence rate within BC and obesity represents a major risk factor. The aim of this study is to analyzed BBC clinicopathological features distribution and determine the potential influence of obesity in BBC in these same features and overall survival....
Exploring the anti-cancer properties of pomegranate peel aqueous extract
Luís, Carla; Sousa, André P.; Costa, Raquel; Maduro, Ana T.; Pais, Patrick J.; Sá, Sara; Gestoso, Álvaro; Fernandes, Flávia; Jerónimo, ElianaThe objective of this work is to evaluate the influence of pomegranate peel extract (PPE) in the behavior of breast cell lines (epithelial and tumor type) and related oxidative metabolism. Fruitbased functional foods have been the target of increasing scientific research for their physiological and pathophysiological properties. Pomegranate (Punica granatum) is a suitable example with both prophylactic and medi...