21 documents found, page 1 of 3
Treatment of Locally Advanced and Metastatic Salivary Gland Cancer: A 10-year E...
Teixeira, Ana Raquel Martins; Agostinho, Cláudia; Dias, Catarina; Soares, Rita; Pina, Marta; Dinis, José; Lopes-Conceição, Luísa; Vieira, CláudiaIntroduction: Scientific evidence regarding salivary gland cancer systemic treatment is limited and the therapeutic approach to locally advanced or metastatic disease is mainly based on consensus. This study aimed to evaluate treatment patterns and outcomes in patients with advanced salivary gland cancer.Methods: We conducted a retrospective cohort study in a comprehensive cancer center in Portugal, including a...
Lineage-specific changes in mitochondrial properties during neural stem cell di...
Soares, Rita; Lourenço, Diogo M.; F. Mota, Isa; Sebastião, Ana M; Xapelli, Sara; Morais, Vanessa A.Neural stem cells (NSCs) reside in discrete regions of the adult mammalian brain where they can differentiate into neurons, astrocytes, and oligodendrocytes. Several studies suggest that mitochondria have a major role in regulating NSC fate. Here, we evaluated mitochondrial properties throughout NSC differentiation and in lineage-specific cells. For this, we used the neurosphere assay model to isolate, expand, ...
Cannabinoid type 2 receptor inhibition enhances the antidepressant and proneuro...
Rodrigues, Rui S.; Moreira, João B.; Mateus, Joana; Barateiro, Andreia; Paulo, Sara L; Vaz, Sandra H.; Lourenço, Diogo M.; Ribeiro, Filipa; Soares, RitaChronic stress is a major risk factor for neuropsychiatric conditions such as depression. Adult hippocampal neurogenesis (AHN) has emerged as a promising target to counteract stress-related disorders given the ability of newborn neurons to facilitate endogenous plasticity. Recent data sheds light on the interaction between cannabinoids and neurotrophic factors underlying the regulation of AHN, with important ef...
Enhancing communication strategies in portuguese Public Administration: challen...
Neto, Luísa; Soares, Rita; Brites, Graça; Ferreira, LuísEffective communication is a critical component for the success of public administration organizations. This study aims to analyse the challenges and identify best practices in communication strategies within a set of Public Administration organizations, with the goal of developing a communication strategy model that can be replicated in other Portuguese public entities and public services, specifically focusin...
Unravelling a novel role for cannabidivarin in the modulation of subventricular...
Lourenço, Diogo M.; Soares, Rita; Sá Santos, Sónia; Mateus, Joana; Rodrigues, Rui S.; Moreira, João B.; Vaz, Sandra H.; Sebastião, Ana M; Solá, SusanaPostnatal neurogenesis has been shown to rely on the endocannabinoid system. Here we aimed at unravelling the role of Cannabidivarin (CBDV), a non-psychoactive cannabinoid, with high affinity for the non-classical cannabinoid receptor TRPV1, on subventricular zone (SVZ) postnatal neurogenesis. Using the neurosphere assay, SVZ-derived neural stem/progenitor cells (NSPCs) were incubated with CBDV and/or 5'-Iodore...
Role of mitochondrial dynamics and metabolism in postnatal neural stem cells di...
Soares, RitaNeural stem cells (NSCs) are found in discrete regions of the adult mammalian brain, the so called neurogenic niches. These niches are localized in the subventricular zone (SVZ) of the lateral ventricles and in the subgranular zone of the hippocampal dentate gyrus (DG). During adulthood, NSCs present the capacity of self-renewal, proliferation and differentiation into neurons, astrocytes and oligodendrocytes, m...
Palipocus: The Use of POCUS in the Palliative Care Setting
Egídio de Sousa, Inês; Monteiro, Margarida; Valente, Tiago; Santos, André; Fiuza, Tiago; Pacheco Mendes, Adriano; Soares, Rita; Teixeira, JorgePalliative care is the holistic care of individuals with serious health-related suffering due to severe illness. The improving survival in malignant and non-malignant diseases results in an ageing population who live with advanced chronic diseases that commonly present to acute care settings. With our improved ability to relief symptoms and treat intercurrent complications, imaging can be an important aspect of...
Population wide testing pooling strategy for SARS-CoV-2 detection using saliva
Esteves, Eduardo; Mendes, Ana Karina; Barros, Marlene; Figueiredo, Cátia; Andrade, Joana; Capelo, Joana; Novais, António; Rebelo, Carla; Soares, RitaSARS-CoV-2 pandemic has forced frequent testing of populations. It is necessary to identify the most cost-effective strategies for the detection of COVID-19 outbreaks. Nasopharyngeal samples have been used for SARS-CoV-2 detection but require a healthcare professional to collect the sample and cause discomfort and pain to the individual. Saliva has been suggested as an appropriate fluid for the diagnosis of COV...
The importance of plantar pressure in the prevention of ulcers in Portuguese pa...
Leal, Catarina; Assis, Márcia; Lima, Márcia; Figueira, Margarida; Soares, Rita; Lima, Daniela; Matos, José PedroObjectives – To understand the relationship between plantar pressures and the ulcers’ occurrence in individuals with neuropathic diabetic feet, using this factor as a possible method of risk assessment and identification. To investigate the association between the epidemiological data and ulcer occurrence. To identify an indicative value for its occurrence. Methods – A quantitative cross-sectional, correlationa...
Validação da Passion Scale para a população portuguesa praticante de exercício ...
Rodrigues, Filipe; Monteiro, Diogo; Soares, Rita; Bernardes, Rui; Teixeira, DiogoO conceito de paixão refere-se a uma forte inclinação para a realização de uma atividade que as pessoas gostam, que acham importante e na qual investem tempo e energia. O Modelo Dualístico da Paixão explora esse conceito nas dimensões harmoniosa e obsessiva e suas implicações na motivação e parâmetros associados à realização de comportamentos. Visando o apoio à modificação comportamental orientada para a prátic...