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Effects of maternal ischemic preconditioning in the colon of newborn rats submi...
Freitas,Maria Andréia Lopes de; Gomes,Rúdnei de Oliveira Luciano; Soares,Bruno Leonardo de Freitas; Artigiani Neto,RicardoPURPOSE: To evaluate the effects of maternal remote ischemic preconditioning (IPCr) in the colonic mucosa of newborn rats subjected to hypoxia and reoxygenation.METHODS:Newborn Wistar rats were divided into three groups. Control Group (CG), Hypoxia and Reoxygenation Group (HRG) and Remote Ischemic Preconditioning Group (IPCrG). Hypoxia and reoxygenation was performed 2x per day, with an interval of 6 hours, on ...
Alprostadil attenuates inflammatory aspects and leucocytes adhesion on renal is...
Soares,Bruno Leonardo de Freitas; Freitas,Maria Andréia Lopes de; Montero,Edna Frasson de Souza; Pitta,Guilherme Benjamin Brandão; Miranda Júnior,FaustoPURPOSE: To evaluate the effects of alprostadil in an experimental model of ischemia and reperfusion injury (IRI) in rat renal tissue.METHODS:Adult male Wistar rats were randomized into three groups Vehicle-treated group(Veh), Alprostadil-treated(Al), and sham(Sh) group. Veh and Al groups had suprarenal aorta occluded for 30 minutes and reperfused for 60 minutes. Saline or 20 µg/kg of Alprostadil was intravenou...