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Mutation profling of cancer drivers in Brazilian colorectal cancer

Santos, Wellington dos; Sobanski, Thais; Carvalho, Ana Carolina de; Evangelista, Adriane Feijó; Matsushita, Marcus; Berardinelli, Gustavo Nóriz

The molecular basis of colorectal cancer (CRC) can guide patient prognosis and therapy. In Brazil, knowledge on the CRC mutation landscape is limited. Here, we investigated the mutation profile of 150 cancer-related genes by next-generation sequencing and associated with microsatellite instability (MSI) and genetic ancestry in a series of 91 Brazilian CRC patients. Driver mutations were found in the APC (71.4%)...

Date: 2019   |   Origin: RepositóriUM - Universidade do Minho
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