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An endoribonuclease of the YicC-like family delays sporulation via sRNA degrada...
Martins, Diogo; Salgueiro, Bruno; Sobral, Daniel; Gragera, Marcos; Hensel, Zach; Henriques, Adriano O.; Romão, Célia V.; Serrano, MónicaFunding Information: This project was supported by award PTDC/BIA-MIC/29293/2017 to M.S. and has received funding from the European Union\u2019s Horizon 2020 research and innovation program under grant agreement No. 857203 to C.V.R. This study was financially supported by the Portuguese Funda\u00E7\u00E3o para a Ci\u00EAncia e Tecnologia (FCT), Projects MOSTMICRO-ITQB with references UIDB/04612/2020, and LS4FUT...
Probe-based metagenomic pathogen detection
Ferreira, Rita; Coelho, Luís; Santos, João Dourado; Sobral, Daniel; Isidro, Joana; Mixão, Verónica; Pinto, Miguel; Nunes, Alexandra; Borrego, Maria JoséPublisher Copyright: Copyright © 2025 Ferreira, Coelho, Santos, Sobral, Isidro, Mixão, Pinto, Nunes, Borrego, Lopo, Oleastro, Sousa, Palminha, Veríssimo, Gargaté, Guiomar, Cordeiro, Macedo, Bajanca-Lavado, Paixão, Duarte, Vieira, Borges and Gomes.; Probe-based pathogen enrichment, followed by NGS, is a promising tool for complex diagnosis, overcoming traditional challenges of shotgun metagenomics, namely small ...
Transcription readthrough is prevalent in healthy human tissues and associated ...
Caldas, Paulo; Luz, Mariana; Baseggio, Simone; Andrade, Rita; Sobral, Daniel; Grosso, Ana RitaWe thank João Neto, Silvia Carvalho, and the remaining Computational Multi-Omics Lab members at UCIBIO for their helpful comments and suggestions. Paulo Caldas was a recipient of a Marie Skłodowska-Curie Postdoctoral Fellowship (FOX-MTN-HORIZON-MSCA - 2021-PF-01-01). This work was financed by national funds from Fundação para a Ciência e Tecnologia (FCT), in the scope of the projects UIDP/04378/2020 and UIDB/04...
Whole Exome Sequencing in Children With Type 1 Diabetes Before Age 6 Years Reve...
Ribeiro, Andreia Fiúza; Fitas, Ana Laura; Pires, Marcela Oliveira; Matoso, Paula; Ligeiro, Dário; Sobral, Daniel; Penha-Gonçalves, CarlosPublisher Copyright: Copyright © 2024 Andreia Fiúza Ribeiro et al.; Aims: This study is aimed at comparing whole exome sequencing (WES) data with the clinical presentation in children with type 1 diabetes onset ≤ 5 years of age (EOT1D). Methods: WES was performed in 99 unrelated children with EOT1D with subsequent analysis to identify potentially deleterious rare variants in MODY genes. High-resolution HLA clas...
The conserved genetic program of male germ cells uncovers ancient regulators of...
Brattig-Correia, Rion; Almeida, Joana M.; Wyrwoll, Margot Julia; Julca, Irene; Sobral, Daniel; Misra, Chandra Shekhar; Di Persio, SaraNational Institutes of Health (1R01LM012832) National Science Foundation (Research Traineeship grant 1735095). Deutsche Forschungsgemeinschaft (329621271). Ministry of Education, Singapore (MOE2018-T2-2-053). Publisher Copyright: © 2024, Brattig-Correia, Almeida, Wyrwoll et al.; Male germ cells share a common origin across animal species, therefore they likely retain a conserved genetic program that defines the...
Turning a vulnerability into a strength
Balau, Ana; Sobral, Daniel; Medeiros, Márcia; Antunes, Sandra; de Carvalho, Maria Duarte; Morais, Inês; Carvalho, Filomena; Gomes, João PauloMalaria remains a global health challenge and despite the considerable progress made in the mortality rate, the 2025 target of the Global Technical Strategy 2016–2030 is still far from being reached. New strategies to improve patient management, prevent severe cases, and reduce deaths, are urgently needed. Exploring interactions between the malaria parasite and host red blood cells (RBCs) offers opportunities t...
The rare DRB1*04:08-DQ8 haplotype is the main HLA class II genetic driver and d...
Caramalho, Iris; Matoso, Paula; Ligeiro, Dário; Paixão, Tiago; Sobral, Daniel; Fitas, Ana Laura; Limbert, Catarina; Demengeot, JocelyneFunding Information: The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the European Foundation for the Study of Diabetes (EFSD/JDRF/Lilly Programme 2016), Maratona da Saúde and Fundação para a Ciência e a Tecnologia (CEECIND/00148/2017 to Iris Caramalho). Acknowledgments Publisher Copyright: Copyright © 2024 Caramalh...
Differential Gene Expression of Malaria Parasite in Response to Red Blood Cell-...
Balau, Ana; Sobral, Daniel; Abrantes, Patrícia; Santos, Inês; Mixão, Verónica; Gomes, João Paulo; Antunes, Sandra; Arez, Ana PaulaInnovative strategies to control malaria are urgently needed. Exploring the interplay between Plasmodium sp. parasites and host red blood cells (RBCs) offers opportunities for novel antimalarial interventions. Pyruvate kinase deficiency (PKD), characterized by heightened 2,3-diphosphoglycerate (2,3-DPG) concentration, has been associated with protection against malaria. Elevated levels of 2,3-DPG, a specific ma...
Identification of biomarkers predictive of metastasis development in early-stag...
Peixoto, Carolina; Lopes, Marta B.; Martins, Marta; Casimiro, Sandra; Sobral, Daniel; Grosso, Ana Rita; Abreu, Catarina; Macedo, DanielaPublisher Copyright: © 2023, The Author(s).; Colorectal cancer (CRC) is the third most common cancer and the second most deathly worldwide. It is a very heterogeneous disease that can develop via distinct pathways where metastasis is the primary cause of death. Therefore, it is crucial to understand the molecular mechanisms underlying metastasis. RNA-sequencing is an essential tool used for studying the transcr...
Predictive and Therapeutic Implications of a Novel PLCγ1/SHP2-Driven Mechanism ...
Cruz-Duarte, Raquel; de Almeida, Cátia Rebelo; Negrão, Magda; Fernandes, Afonso; Borralho, Paula; Sobral, Daniel; Gallego-Paez, Lina M.; Machado, DanielP. Borralho reports grants from Roche and Novartis, as well as personal fees from Bayer and AstraZeneca outside the submitted work. D. Machado reports personal fees from Amgen and Merck outside the submitted work. H. Mansinho reports grants from AstraZeneca; nonfinancial support from AstraZeneca; and personal fees from Roche, Pfizer, Pierre Fabre, Incyte, BMS, Novartis, Amgen, Servier, Merck Serono, and Grunent...