2 documents found, page 1 of 1
Cytogenotoxic and oxidative status evaluation of Morinda citrifolia
Moraes, Germano Pinho de; Alencar, Marcus Vinícius Oliveira Barros de; Islam, Torequl; Araújo, Lidiane da Silva; Sobral, André Luiz PinhoCancer is one of the most leading causes of death worldwide. Morinda citrifolia was reported to have antitumor effects. Cisplatin (CDDP), Doxorubicin (DOX) and Cyclophosphamid (CPA) are the known effective chemotherapeutics, despite of having several side effects. This study evaluated antitumoral and oxidative effects of the aqueous extract of the fruit of M. critrifolia (AEMC) (15, 30, 60 and 120 µg/mL) in com...
Serum oxidative stress markers and genotoxic profile induced by chemotherapy in...
Gomes Júnior, Antonio Luiz; Paz, Marcia Fernanda Correia Jardim; Silva, Laís Iasmin Soares da; Carvalho, Simone da Costa e SilvaThe aim of this study was to evaluate the oxidative parameters of erythrocytes and genotoxicity in leukocytes of patients with breastcancer.Oxidativeparametersweredetectedbyspectrophotometryandgenotoxicdamagebysinglecellgelelectrophoresis. Twenty-eight women with breast cancer were monitored before chemotherapy and after the second and fourth cycles of therapy withcyclophosphamideanddoxorubicin.Afterthefourthcy...