9 documents found, page 1 of 1
Editorial
Díaz Merino, Giselle; Sobral, JoãoIt is with great pleasure that we present this edition of the DATJournal - Design, Art, and Technology which brings, in a special format, the scientific articles from the 13th Brazilian Congress on Research and Development in Design (P&D), held at the University of the Region of Joinville - Univille, in 2018. P&D, the main national event in the Design area, has maintained the tradition in scientific dis...
An Approach Relied on Design and Materials in Univille´s PPGDesign Realm
Aguiar, Victor; Santos, Adriane; Sobral, João; Everli, MarliThis report presents the structuring of technical-scientific contents associatedwith the subject Materials and Processes within the Graduate Program in Design of the University of the Region of Joinville (PPGDesign /Univille). Due to the professional nature of the master’s degree, the translation of scientific and technological knowledge into technical qualification, including applicability, was the north of th...
A percepção dos adeptos de futebol em relacão aos investimentos dos patrocínios...
Sobral, JoãoA oportunidade que me foi oferecida, de fazer parte da direção de um clube de futebol da primeira divisão portuguesa, despertou em mim um especial interesse em estudar a vertente dos patrocínios nos clubes de futebol. A minha função seria efetuar uma análise financeira e comercial no peso dos patrocínios, da sua estrutura através dos seus valores de investimento e encontrar novas fontes de financiamento para es...
FUT2: filling the gap between genes and environment in Behçet's disease?
Xavier, Joana; Sousa, Inês; Matos, Mafalda; Sobral, João; Ghaderibarmi, Fahmida; Shahram, Farhad; Nadji, Abdolhadi; Oliveira, Manuela; Shafiee, MojaradBackground Behçet’s disease (BD) is a multisystemic immune and inflammatory disorder whose aetiology remains unclear. In order to identify novel susceptibility loci, we performed the first genome-wide association study (GWAS) for BD in the Iranian population using a DNA pooling strategy. Methods Two replicate pools of 292 BD cases and of 294 age- and sex-matched controls were allelotyped in quadruplicate on the...
Genetic Variants Underlying Risk of Intracranial Aneurysms: Insights from a GWA...
Abrantes, Patrícia; Santos, Maria M.; Sousa, Inês; Xavier, Joana M.; Francisco, Vânia; Krug, Tiago; Sobral, João; Matos, Mafalda; Martins, MadalenaSubarachnoid hemorrhage (SAH) is a life-threatening event that most frequently leads to severe disability and death. Its most frequent cause is the rupture of a saccular intracranial aneurysm (IA), which is a blood vessel dilation caused by disease or weakening of the vessel wall. Although the genetic contribution to IA is well established, to date no single gene has been unequivocally identified as responsible...
Replication of the CELSR1 association with ischemic stroke in a Portuguese case...
Gouveia, Liliana O.; Sobral, João; Vicente, A.M.; Ferro, José M.; Oliveira, Sofia A.OBJECTIVES: Replication of GWAS association findings remains the gold standard for results validation. Our aim was to test the association of four polymorphisms (rs1671021 in LLGL2, rs753307 in RUVBL2, rs6007897 and rs4044210 in CELSR1) previously identified as ischemic stroke (IS) risk factors in a phased GWAS performed on 6341 Japanese individuals [1]. METHODS: These polymorphisms were genotyped in a Portugue...
Variants in the inflammatory IL6 and MPO genes modulate stroke susceptibility t...
Manso, Helena; Krug, Tiago; Sobral, João; Albergaria, Isabel; Gaspar, Gisela; Ferro, José M.; Oliveira, Sofia A.; Vicente, A.M.There is substantial evidence that inflammation within the central nervous system contributes to stroke risk and recovery. Inflammatory conditions increase stroke risk, and the inflammatory response is of major importance in recovery and healing processes after stroke. We investigated the role of inflammatory genes IL1B, IL6, MPO, and TNF in stroke susceptibility and recovery in a population sample of 672 patie...
Replication of the CELSR1 association with ischemic stroke in a Portuguese case...
Gouveia, Liliana O.; Sobral, João; Vicente, Astrid M.; Ferro, José; De Oliveira, SofiaObjectives: Replication of GWAS association findings remains the gold standard for results validation. Our aim was to test the association of four polymorphisms (rs1671021 in LLGL2, rs753307 in RUVBL2, rs6007897 and rs4044210 in CELSR1) previously identified as ischemic stroke (IS) risk factors in a phased GWAS performed on 6341 Japanese individuals. Methods: These polymorphisms were genotyped in a Portuguese s...
Association of a genetic variant in the ALOX5AP with higher risk of ischemic st...
Domingues-Montanarie, Sophie; Fernández-Cadenas, Israel; Rio-Espinola, Alberto del; Corbeto, Natalia; Krug, Tiago; Manso, Helena; Gouveia, LilianaBackground: Variants in the 5-lipoxygenase-activating protein (ALOX5AP) and phosphodiesterase 4D (PDE4D) genes have first been associated with ischemic stroke (IS) through whole-genome linkage screens. However, association studies obtained conflicting results. We aimed to investigate the contribution of selected single nucleotide polymorphisms (SNPs) in these genes for the first time in a large Iberian populati...