88 documents found, page 1 of 9
The Impact of a Western Diet and Resistance Training in a Rat Model of Mammary ...
Silva, Jessica; Ferreira, Rita; Neuparth, Maria J.; Seixas, Fernanda; Ginja, Mário; Pires, Maria J.; Faustino-Rocha, Ana I.; Duarte, José AlbertoThis study aimed to investigate the impact of a Western diet and resistance training on cardiac remodeling in a rat model of chemically induced mammary cancer. Fifty-six female Wistar rats were randomly assigned to one of eight experimental groups, evaluating the impact of Western and standard diets, exercise and sedentarism, and the induction of mammary cancer. Mammary cancer was induced via the intraperitonea...
Exploring the Chemopreventive and Antioxidant Effects of Spearmint Leaf Hydroet...
Jesus, Tiago M.; Azevedo, Tiago; Silva-Reis, Rita; Ferreira, Tiago; Nascimento-Gonçalves, Elisabete; Medeiros, Catarina; Ferreira, João; Gama, AdelinaHuman papillomavirus (HPV) is the most common sexually transmitted infectious agent and, in cases of persistent infection, may cause cancer. This study evaluated the toxicological and antitumor properties of Mentha spicata extract (MSE) in KP14HPV16 mice, which carry HPV16 oncogenes. Thirty‑three female FVB/n mice (Mus musculus), including 17 HPV‑transgenic and 16 wild‑type (WT) mice, were divided into six grou...
Effects of Ladder-Climbing Exercise on Mammary Cancer: Data from a Chemically I...
Silva, Jessica; Azevedo, Tiago; Aires, Inês; Medeiros, Catarina; Neuparth, Maria J.; Seixas, Fernanda; Ferreira, Rita; Faustino-Rocha, Ana I.Breast cancer remains a significant global health issue, affecting both humans and companion animals, particularly female dogs and cats, where mammary tumors are among the most common cancers. Strategies to minimize the impact of this disease on patients, pet owners, and veterinary medicine are essential. This study analyses the effects of resistance training on the development of chemically induced mammary can...
Do (xeno)estrogens pose a risk to earthworms? Soy isoflavones and estradiol imp...
Azevedo, Tiago; Silva-Reis, Rita; Medeiros-Fonseca, Beatriz; Gonçalves, Mariana; Mendes, Gabriel; Roboredo, Marta; Rocha, Maria J.; Peixoto, FranciscoUnderstanding the impact of endocrine disruptor compounds (EDCs) across a wide range of species is crucial, given their ubiquitous presence. Although invertebrate species lack sex steroid hormone pathways, they exhibit sensitivity to EDCs, which could affect population dynamics. This study assessed reproductive endpoints and oxidative stress parameters in Eisenia fetida following exposure to estradiol and soy i...
Cystic Fibrosis modulator drugs inhibit migration of colorectal cancer cells
Vicente, Luana; Barros, Patrícia; Gonçalves, Vânia; Oliveira, Paula A.; Jordan, Peter; Matos, PauloColorectal cancer (CRC) remains a leading cause of cancer-related mortality, driven by complex genetic, epigenetic, and microenvironmental factors. Recent findings implicate the cystic fibrosis transmembrane conductance regulator (CFTR) ion channel in CRC progression, as CFTR levels are notably reduced in sporadic CRCs, particularly in advanced and metastatic tumors, correlating with poorer patient outcomes. Ad...
The first full study of heavy metal(loid)s in western-European hedgehogs (Erina...
Baptista, Catarina Jota; Fernanda Seixas, Fernanda; Gonzalo-Orden, José M.; Patinha, Carla; Pato, Pedro; Silva, Eduardo Ferreira da; Casero, MaríaThe western-European hedgehog (Erinaceus europaeus) is an insectivore with a wide distribution in Portugal and a potential tool for biomonitoring relevant One Health hazards, including heavy metal(loid)s’ pollution. The aim of this study was to positively contribute to the current knowledge about the metal(loid) pollution in Portugal. Forty-six hedgehogs (from rescue centres; with known provenance) were necrops...
Exploring the therapeutic potential of Quercus ilex acorn extract in papillomav...
Medeiros-Fonseca, Beatriz; Faustino-Rocha, Ana I.; Pires, Maria João; Neuparth, Maria João; Vala, Helena; Nóbrega, Carmen; Gouvinhas, IreneBackground and Aim: Papillomaviruses (PVs) infections have been documented in numerous animal species across different regions worldwide. They often exert significant impacts on animal health and livestock production. Scientists have studied natural products for over half a century due to their diverse chemical composition, acknowledging their value in fighting cancer. Acorns (Quercus ilex) are believed to have...
Aloysia citrodora extract as a chemopreventive agent against HPV16-induced lesi...
Medeiros-Fonseca, Beatriz; Faustino-Rocha, Ana I.; Silva, Jéssica; Silva, Mónica G.; Pires, Maria João; Neuparth, Maria João; Vala, HelenaAim: Aloysia citrodora has a long history of traditional use in treating various ailments. This study evaluated the in vivo chemopreventive efficacy and systemic toxicity of an extract of A. citrodora in a transgenic mouse model of HPV16 (human papillomavirus type 16)-induced cancer. Methods: The experiment involved six groups (n = 5): group 1 (G1, wild-type (WT), water), group 2 (G2, HPV, water), group 3 (G3, ...
Prostate cancer.
Faustino-Rocha, Ana; Oliveira, Paula A.The prostate is the largest accessory gland of the male reproductive tract. Together with seminal vesicles and bulbourethral glands, the prostate is responsible for the production of an alkaline fluid that forms part of the seminal fluid. The prostates of men over 40 years of age are commonly affected by several pathologies, such as benign prostate hyperplasia and cancer. Prostate cancer is one of the most freq...
Relation between infrared thermometry and thermal imaging for assessment of rod...
Oliveira, Paula A.; Gonçalves, Lio; Gonçalves, Mariana; Venâncio, Carlos; Azevedo, Tiago; Ribeiro, Carla; Reis, Rita; Faustino-Rocha, Ana IAnimals have been used for biomedical research since ancient times. Humane endpoints have been increasingly implemented during experimental protocols to prevent or alleviate animals’ suffering. Body temperature is an indicator of stress or anxiety. Infrared thermometer (IRT) and infrared thermal imaging camera (TIC) are commercially available for temperature measurement. This study aimed to determine mice and r...