17 documents found, page 1 of 2
A One pathology multicentre Portuguese approach to thyroid tumours of dogs and ...
Gaspar, Tiago; Borges, Inês; Canberk, Sule; Monteiro, Alexandra; Catarino, José; Pinto, Mafalda; Teixeira, Elisabete; Canadas-Sousa, Ana; Branco, SandraThyroid tumours are the most common endocrine tumours of dogs and cats. Feline thyroid tumours are essentially functional adenomas curable with thyroidectomy, whereas most canine thyroid tumours are non-functional carcinomas either unresectable or recurrent within two years in up 50%. The oncobiology of these tumours remains unclear, but investigating this aspect could contribute to the development of targeted ...
Significance of Furin Expression in Thyroid Neoplastic Transformation
Azevedo, Maria Teresa; Macedo, Sofia; Canberk, Sule; Cardoso, Luís; Gaspar, Tiago Bordeira; Pestana, Ana; Batista, Rui; Sobrinho-Simões, ManuelAngiotensin-Converting Enzyme 2 (ACE2), Transmembrane Serine Protease 2 (TMPRSS2), and Furin were known to be key players in the SARS-CoV-2 infection, and the thyroid gland was revealed to be one of the relevant targets of the virus. Regardless of the viral infection, the expression of these molecules in the thyroid gland and their putative role in the neoplastic transformation of the thyrocytes has not been th...
Comprehensive Assessment of TERT mRNA Expression across a Large Cohort of Benig...
Pestana, Ana; Batista, Rui; Celestino, Ricardo; Canberk, Sule; Sobrinho-Simões, Manuel; Soares, PaulaThe presence of TERT promoter (TERTp) mutations in thyroid cancer have been associated with worse prognosis features, whereas the extent and meaning of the expression and activation of TERT in thyroid tumours is still largely unknown. We analysed frozen samples from a series of benign and malignant thyroid tumours, displaying non-aggressive features and low mutational burden in order to evaluate the presence of...
NIS expression in thyroid tumors, relation with prognosis clinicopathological a...
Tavares, Catarina; Coelho, Maria João; Eloy, Catarina; Melo, Miguel; da Rocha, Adriana Gaspar; Pestana, Ana; Batista, Rui; Ferreira, Luciana BuenoThyroid cancer therapy is based on surgery followed by radioiodine treatment. The incorporation of radioiodine by cancer cells is mediated by sodium iodide symporter (NIS) (codified by the SLC5A5 gene), that is functional only when targeted to the cell membrane. We aimed to evaluate if NIS expression in thyroid primary tumors would be helpful in predicting tumor behavior, response to therapy and prognosis. NIS ...
Dynamin-Related Protein 1 at the Crossroads of Cancer
Lima, Ana Rita; Santos, Liliana; Correia, Marcelo; Soares, Paula; Sobrinho-Simões, Manuel; Melo, Miguel; Máximo, ValdemarMitochondrial dynamics are known to have an important role in so-called age-related diseases, including cancer. Mitochondria is an organelle involved in many key cellular functions and responds to physiologic or stress stimuli by adapting its structure and function. Perhaps the most important structural changes involve mitochondrial dynamics (fission and fusion), which occur in normal cells as well as in cells ...
mTOR Pathway in Papillary Thyroid Carcinoma: Different Contributions of mTORC1 ...
Tavares, Catarina; Eloy, Catarina; Melo, Miguel; Gaspar da Rocha, Adriana; Pestana, Ana; Batista, Rui; Bueno Ferreira, Luciana; Rios, ElisabeteThe mammalian target of rapamycin (mTOR) pathway is overactivated in thyroid cancer (TC). We previously demonstrated that phospho-mTOR expression is associated with tumor aggressiveness, therapy resistance, and lower mRNA expression of SLC5A5 in papillary thyroid carcinoma (PTC), while phospho-S6 (mTORC1 effector) expression was associated with less aggressive clinicopathological features. The distinct behavior...
CRABP1, C1QL1 and LCN2 are biomarkers of differentiated thyroid carcinoma, and ...
Celestino, Ricardo; Nome, Torfinn; Pestana, Ana; Hoff, Andreas M.; Gonçalves, A. Pedro; Pereira, Luísa; Cavadas, Bruno; Eloy, Catarina; Bjøro, TrineBackground: The prognostic variability of thyroid carcinomas has led to the search for accurate biomarkers at the molecular level. Follicular thyroid carcinoma (FTC) is a typical example of differentiated thyroid carcinomas (DTC) in which challenges are faced in the differential diagnosis. Methods: We used high-throughput paired-end RNA sequencing technology to study four cases of FTC with different degree of c...
TERT promoter mutations in pancreatic endocrine tumours are rare and mainly fou...
Vinagre, João; Nabais, Joana; Pinheiro, Jorge; Batista, Rui; Oliveira, Rui Caetano; Gonçalves, António Pedro; Pestana, Ana; Reis, MartaOne of the hallmarks of cancer is its unlimited replicative potential that needs a compensatory mechanism for the consequential telomere erosion. Telomerase promoter (TERTp) mutations were recently reported as a novel mechanism for telomerase re-activation/expression in order to maintain telomere length. Pancreatic endocrine tumors (PETs) were so far recognized to rely mainly on the alternative lengthening of t...
Primary squamous cell carcinoma of the thyroid diagnosed as anaplastic carcinom...
Bolfi, Fernanda [UNESP]; Domingues, Maria A. C. [UNESP]; Sobrinho-Simões, Manuel; Soares, Paula; Celestino, Ricardo; Castilho, Emanuel C. [UNESP]Made available in DSpace on 2015-12-07T15:30:31Z (GMT). No. of bitstreams: 0 Previous issue date: 2014. Added 1 bitstream(s) on 2015-12-07T15:52:58Z : No. of bitstreams: 1 PMC4175754.pdf: 2923504 bytes, checksum: 44acfab2f76a328b9de819d5069f006a (MD5); A case of primary squamous-cell carcinoma (SCC) of the thyroid which had been initially diagnosed as an anaplastic carcinoma (ATC) is described: female, 73 years...
Polymorphisms in the TNFA and IL6 Genes Represent Risk Factors for Autoimmune T...
Durães, Cecília; Moreira, Carla S.; Alvelos, Inês; Mendes, Adélia; Santos, Liliana R.; Machado, José Carlos; Melo, Miguel; Esteves, CésarBackground Autoimmune thyroid disease (AITD) comprises diseases including Hashimoto's thyroiditis and Graves' disease, both characterized by reactivity to autoantigens causing, respectively, inflammatory destruction and autoimmune stimulation of the thyroid-stimulating hormone receptor. AITD is the most common thyroid disease and the leading form of autoimmune disease in women. Cytokines are key regulators of t...