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The Acute Effects of a Fast-Food Meal Versus a Mediterranean Food Meal on the A...

Silva, D; Mendes, FC; Stanzani, V; Moreira, R; Pinto, M; Beltrão, M; Sokhatska, O; Severo, M; Padrão, P; Garcia-Larsen, V; Delgado, L; Moreira, A

Background/Objectives: This study aimed to assess the acute effects of two isoenergetic but micronutrient-diverse meals—a Mediterranean-like meal (MdM) and a fast food-like meal (FFM)—on the autonomic nervous system (ANS), lung function, and airway inflammation response. Methods: Forty-six participants were enrolled in a randomized crossover clinical trial, consuming two isoenergetic meals: FFM (burger, fries, ...



Component-resolved diagnosis in childhood and prediction of asthma in early ado...

Farraia, M; Mendes, FC; Sokhatska, O; Rama, T; Severo, M; Custovic, A; Cavaleiro Rufo, J; Barros, H; Moreira, A

"Introduction Component-resolved diagnosis (CRD) has been decisive in exploring the mechanisms of IgE sensitization, but the predictive ability to detect asthma has not been addressed. We aim to develop and evaluate the performance of a personalized predictive algorithm for asthma that integrates information on allergic sensitization using CRD. Methods One thousand one hundred one twenty-five children from the ...


Sensitization trajectories to multiple allergen components in a population-base...

Farraia, M; Mendes, FC; Sokhatska, O; Severo, M; Cavaleiro Rufo, J; Barros, H; Moreira, A

BackgroundThe characteristics of allergic sensitization profiles can differ between populations and geographic regions, contributing differently to the association with allergic diseases. Consequently, the sensitization trajectories found in previous studies conducted in Northern Europe may not apply in Southern European countries. ObjectiveTo identify trajectories of allergic sensitization profiles during chil...


Neighbourhood green and blue spaces and allergic sensitization in children: A l...

Paciência, I; Moreira, A; Moreira, C; Cavaleiro Rufo, J; Sokhatska, O; Rama, T; Hoffimann, E; Santos, AC; Barros, H; Ribeiro, AI

Evidence on the effect of natural environments on atopy in children is limited and inconsistent, disregarding the time-varying and cumulative exposures throughout the life course. To assess critical periods of exposure as well as the effect of longitudinal trajectories of exposure to green and blue spaces on the development of allergic sensitization in children at the age of 10 years. A longitudinal study was c...


Hypersensitivity pneumonitis: Main features characterization in a Portuguese co...

Santos, V; Martins, N; Sousa, C; Jacob, M; Padrão, E; Melo, N; Mota, PC; Bastos, HN; Guimarães, S; Moura, CS; Sokhatska, O; Cunha, R; Pereira, J

Hypersensitivity pneumonitis (HP) is an interstitial lung disease (ILD) which varies in prevalence across the world, depending on disease definition, diagnostic methods, exposure type and intensity, geographical environments, agricultural and industrial practices, and host risk factors. This study aimed to deepen knowledge about HP's clinical characteristics, diagnosis and functional and imaging features in a c...


Meal-exercise challenge and physical activity reduction impact on immunity and ...

Silva, D; Moreira, R; Sokhatska, O; Beltrão, M; Montanha, T; Garcia-Larsen, V; Villegas, R; Severo, M; Pizarro, A; Pinto, M; Martins, C; Duarte, A

Background: The effect of a pre-exercise meal as countermeasure to exercise induced immunodepression is poorly known. Also, sedentary behavior is associated with increased cardiometabolic risk but studies on immune changes are lacking. Therefore, we aimed to assess: 1) the impact of a pre-exercise Mediterranean meal (MdM) compared with a fast-food type meal (FFM) on exercise-induced immunological changes and 2)...


Serum metalloproteinases 1 and 7 in the diagnosis of idiopathic pulmonary fibro...

Morais, A; Beltrão, M; Sokhatska, O; Dias, CC; Melo, N; Mota, P; Marques, A; Delgado, L

INTRODUCTION: Accurate diagnosis of idiopathic pulmonary fibrosis (IPF) has important therapeutic and prognostic implications and would be greatly aided by reliable diagnostic biomarkers as IPF has sometimes overlapping features with other interstitial lung diseases (ILD). OBJECTIVES: To explore the value of serum metalloproteinases (MMP) 1 and 7 levels in the differential diagnosis of IPF with other ILD. METHO...


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