5 documents found, page 1 of 1
The effects of benralizumab on lung volumes and airway resistance in severe eos...
Gerardo, António Madeira; Alves, Carolina da Silva; Gomes, Margarida; Pardal, Cecília; Sokolova, Anna; Liberato, Hedi; Mendes, Ana; Tonin, FernandaIntroduction: Add-on biological monoclonal antibodies such as benralizumab (anti-IL-5Ra) are recommended by international guidelines to reduce exacerbations in severe eosinophilic asthma (SEA). However, few studies have assessed the impact of these therapies on lung function-related outcomes. Our goal was to evaluate the effectiveness of benralizumab on lung function, including lung volumes and airway resistanc...
Optimizing the use of systemic corticosteroids in severe asthma (ROSA II projec...
Marques, João; Duarte-Ramos, Filipa; Ferreira, Manuel Branco; Lima, Ricardo; Lopes, Cristina; Sokolova, Anna; Tonin, Fernanda StumpfAlthough the prevalence of severe asthma is not high (5-10% of patients), it is responsible for a large part of the overall disease burden and costs (50-60% of total costs), especially if the condition remains uncontrolled (which occurs in around 40% of cases). Currently, for patients without disease control or presenting frequent exacerbations despite optimal therapy, add-on treatments, traditionally long-acti...
Reducing oral corticosteroids in severe asthma (ROSA Project): a nationwide Por...
Loureiro, Cláudia Chaves; Branco Ferreira, Manuel; Ferreira, Jorge; Lima, Ricardo; Marques, João; Sokolova, Anna; Tonin, Fernanda S.Introduction and objectives: We aimed to build a national consensus to optimize the use of oral corticosteroids (OCS) in severe asthma in Portugal. Material and methods: A modified 3-round Delphi including 65 statements (topics on chronic systemic corticotherapy, therapeutic schemes, asthma safety and monitoring) was performed via online platform (October-November 2019). A five-point Likert-type scale was used ...
The Portuguese Severe Asthma Registry: Development, Features, and Data Sharing ...
Sá-Sousa, Ana; Fonseca, João Almeida; Pereira, Ana Margarida; Ferreira, Ana; Arrobas, Ana; Mendes, Ana; Drummond, Marta; Videira, Wanda; Costa, TiagoThe Portuguese Severe Asthma Registry (Registo de Asma Grave Portugal, RAG) was developed by an open collaborative network of asthma specialists. RAG collects data from adults and pediatric severe asthma patients that despite treatment optimization and adequate management of comorbidities require step 4/5 treatment according to GINA recommendations. In this paper, we describe the development and implementation ...
The portuguese severe asthma registry : development, features, and data sharing...
Sousa, Ana Sá; Fonseca, João Almeida; Pereira, Ana Margarida; Ferreira, Ana; Arrobas, Ana; Mendes, Ana; Drummond, Marta; Videira, Wanda; Costa, TiagoThe Portuguese Severe Asthma Registry (Registo de Asma Grave Portugal, RAG) was developed by an open collaborative network of asthma specialists. RAG collects data from adults and pediatric severe asthma patients that despite treatment optimization and adequate management of comorbidities require step 4/5 treatment according to GINA recommendations. In this paper, we describe the development and implementation ...