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Chronic treatment with ivabradine does not affect cardiovascular autonomic cont...

Silva, Fernanda Cacilda dos Santos; Paiva, Franciny Aparecida; Ribeiro, Flavia Camargos de Figueiredo Müller; Caldeira, Henrique Martins Arantes

A low resting heart rate (HR) would be of great benefit in cardiovascular diseases. Ivabradine-a novel selective inhibitor of hyperpolarization-activated cyclic nucleotide gated (HCN) channels- has emerged as a promising HR lowering drug. Its effects on the autonomic HR control are little known. This study assessed the effects of chronic treatment with ivabradine on the modulatory, reflex and tonic cardiovascul...

Date: 2018   |   Origin: Oasisbr
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