13 documents found, page 1 of 2
Practical Guidance on the Detection of NTRK Fusions in Sarcomas
Fernandes, Isabel; Macedo, Daniela; Gouveia, Emanuel; Ferreira, Ana; Lima, Jorge; Lopez, Dolores; Melo-Alvim, Cecília; Carvalho, Alice; Tavares, PauloPublisher Copyright: © 2025 CELOM. All rights reserved.; Sarcomas are a rare and heterogeneous group of mesenchymal malignant tumors and account for approximately 1% of all adult cancers and around 20% of all pediatric solid tumors in Europe. Technology advances have enabled a more accurate and efficient characterization of the molecular mechanisms underlying the pathogenesis of sarcoma subtypes and revealed no...
Prevalence of high-grade endometrioid endometrial cancer of no specific molecul...
Casanova, João; Ramos, Ana Sofia; Babiciu, Alexandru; Moutinho, Filipa; Tripepi, Marta; da Costa, Ana Gomes; Serra, Sofia Silvério; Costa, TeresaCopyright © 2025 The Author(s). Published by Elsevier B.V. All rights reserved.; BACKGROUND: Endometrial cancer of no specific molecular profile (NSMP) represents the most prevalent molecular subtype of endometrial cancer, comprising over 50 % of all diagnoses. Although studies have explored the prevalence of the NSMP subtype, to our knowledge, no systematic review or meta-analysis has specifically targeted gra...
Prognosis of polymerase epsilon (POLE) mutation in high-grade endometrioid endo...
Casanova, Joao; Duarte, Gonçalo Silva; da Costa, Ana Gomes; Catarino, Ana; Nave, Mónica; Antunes, Telma; Silvério Serra, Sofia; Dias, Sara SimõesFunding Information: This work in the context of the “Women's Health and Maternal Fetal Research Group” was partially co-financed by Hospital da Luz Lisboa under the initiative “Luz Investigação”. Dr. Abu-Rustum was supported in part by a National Cancer Institute/National Institutes of Health Cancer Center Support Grant ( P30 CA008748 ). The funding sources were not involved in study design; collection, analys...
Molecular classification of endometrial cancer
Casanova, João; da Costa, Ana G.; Lopes, Ana Pestana; Catarino, Ana; Nave, Mónica; Sousa, Ana Carla; Lima, JorgePublisher Copyright: Copyright © 2024 Casanova, da Costa, Lopes, Catarino, Nave, Sousa and Lima.; Background: Since the seminal publication of the TCGA consortium in 2013, the molecular classification of endometrial cancer has been widely accepted as a new and powerful tool to better understand the natural history of this malignancy. Adoption of routine molecular classification around the world has been limited...
Obstetric Intensive Care Admissions and Neonatal Outcomes
Rocha, Filipa Ramalho; Gonçalves, Tiago Neto; Xavier-Ferreira, Maria Inês; Laranjeira, Francisco; Magalhães, Gonçalo Meleiro; Lopes, Maria InêsFunding Information: This research was partially funded by the Hospital da Luz Lisboa under the initiative \u201CLuz Investiga\u00E7\u00E3o\u201D. The funding sources were not involved in the study design; collection, analysis and interpretation of data; the writing of the report; or the decision to submit the paper for publication. Publisher Copyright: © 2024 by the authors.; Background and Objectives: Materna...
Essential Trace Elements Status in Portuguese Pregnant Women and Their Associat...
Bracchi, Isabella; Guimarães, Juliana; Rodrigues, Catarina; Azevedo, Rui; Coelho, Cláudia Matta; Pinheiro, Cátia; Morais, Juliana; Barreiros-Mota, InêsCobalt (Co), copper (Cu), manganese (Mn), molybdenum (Mo), and zinc (Zn) are essential trace elements (ETEs) and important cofactors for intermediary metabolism or redox balance. These ETEs are crucial during pregnancy, their role on specific pregnancy outcomes is largely unknown. This prospective study (#NCT04010708) aimed to assess urinary levels of these ETEs in pregnancy and to evaluate their association wi...
Natural Killer Cell Receptors and Endometriosis
Reis, José Lourenço; Rosa, Natacha Nurdine; Ângelo-Dias, Miguel; Martins, Catarina; Borrego, Luís Miguel; Lima, JorgeFunding: This work in the context of the “Women’s Health and Maternal & Fetal Research Group” was partially co-financed by Hospital da Luz Lisboa under the initiative “Luz Investigação”.; Endometriosis is a chronic inflammatory disorder, characterized by the presence of endometrial cells outside the uterine cavity. An increasing number of studies correlate the immune system with endometriosis, particularly NK r...
Macrophage Resistance to Ionizing Radiation Exposure Is Accompanied by Decrease...
Pinto, Ana Teresa; Machado, Ana Beatriz; Osório, Hugo; Pinto, Marta Laranjeiro; Vitorino, Rui; Justino, Gonçalo; Santa, Cátia; Castro, FláviaLA/P/0056/2020 and POCI-01-0145-FEDER-31859/2017), the Program “COMPETE Programa Operacional Factores de Competitividade” (FCOMP-01-0124-FEDER-010915) QREN, the European Union (FEDER—Fundo Europeu de Desenvolvimento Regional), Proteostasis COST Action (BM1307), by The National Mass Spectrometry Network (POCI-01-0145-FEDER-402-022125 Ref. ROTEIRO/0028/2013), and the Prize L’Óreal for Women in Science (Foundation...
Association of B Cells with Idiopathic Recurrent Pregnancy Loss
Ângelo-Dias, Miguel; Martins, Catarina; Dias, Sara Simões; Borrego, Luís Miguel; Lima, JorgeRecurrent pregnancy loss (RPL) affects 1-2% of women and is defined as having experienced two or more failed pregnancies. In almost 50% of cases, the causes are idiopathic (IRPL), but increasing evidence has suggested an immunological cause. B cells are known to provide crucial support for a successful pregnancy outcome. However, their involvement in the mechanisms underlying IRPL is still unclear. This systema...
Características Demográficas e Profissionais dos Especialistas em Ginecologia-O...
Pereira Da Silva, Daniel; Nogueira-Silva, Cristina; Lima, Jorge; Braga, António; Saraiva, João; Águas, Fernanda; Nogueira-Martins, Nuno; Santo, SusanaIntroduction: The demographic and professional characteristics of specialists in Obstetrics and Gynecology registered in Portugal are presented and current and future needs assessed. Material and Methods: An analysis of the data from Instituto Nacional de Estatística, Ordem dos Médicos and a survey sent to the directors of the departments of Obstetrics and Gynecology of Portuguese hospitals was perfomed. In ord...