3 documents found, page 1 of 1
Polymorphisms within the TNFSF4 and MAPKAPK2 Loci influence the risk of develop...
Sánchez-Maldonado, Jose Manuel; Moñiz-Díez, Ana; ter Horst, Rob; Campa, Daniele; Cabrera-Serrano, Antonio José; Martínez-Bueno, ManuelHere, we assessed whether 36 single nucleotide polymorphisms (SNPs) within the <i>TNFSF4</i> and <i>MAPKAPK2</i> loci influence the risk of developing invasive aspergillosis (IA). We conducted a two-stage case control study including 911 high-risk patients diagnosed with hematological malignancies that were ascertained through the aspBIOmics consortium. The meta-analysis of the discovery and replication populat...
Azole-Resistance in Aspergillus terreus and Related Species: An Emerging Proble...
Zoran, Tamara; Sartori, Bettina; Sappl, Laura; Aigner, Maria; Sánchez-Reus, Ferran; Rezusta, Antonio; Chowdhary, Anuradha; Taj-Aldeen, Saad J.Objectives: Invasive mold infections associated with Aspergillus species are a significant cause of mortality in immunocompromised patients. The most frequently occurring aetiological pathogens are members of the Aspergillus section Fumigati followed by members of the section Terrei. The frequency of Aspergillus terreus and related (cryptic) species in clinical specimens, as well as the percentage of azole-resi...
Common genetic polymorphisms within NFκB-Related genes and the risk of developi...
Lupianez, Carmen B.; Villaescusa, Maria T.; Carvalho, Agostinho; Springer, Jan; Lackner, Michaela; Sanchez-Maldonado, Jose M.; Canet, Luz M.Invasive Aspergillosis (IA) is an opportunistic infection caused by Aspergillus, a ubiquitously present airborne pathogenic mold. A growing number of studies suggest a major host genetic component in disease susceptibility. Here, we evaluated whether 14 single-nucleotide polymorphisms within NF kappa B1, NF kappa B2, RelA, RelB, Rel, and IRF4 genes influence the risk of IA in a population of 834 high-risk patie...