Therapeutic approaches based on nucleic acids to modulate cell activity have recently gained attention. These molecules arise from complex biotechnological processes, requiring effective manufacturing strategies, high purity, and precise quality control to be used as biopharmaceuticals. One of the most critical and time-consuming steps for nucleic acids-based biotherapeutics manufacturing is their purification,...
The occurrence of non-Hodgkin lymphoma in patients previously treated for Hodgkin's disease has already been described and is explained by an iatrogenic immunologic deficit. The authors describe a 60 year-old patient with Hodgkin's disease ( sclero-nodular) which in the course of therapy with MOPP developed a superior vena cava syndrome dueto an "explosive proliferation" of mediastinal and cervical ade nopat...
The authors describe the case of a 26 year old male with clinicai and radiological features suggesting a pulmonary suppurative disease (pulmonary abscess vs. necrotizing pneumonia). ln spite of the antibiotic treatment the features of a serious grave infection lasted unchanged. An Echinococcus pulmonary infection was suspected upon the findings of a pulmonary cavitation with movable residues (water lily sign...
The authors present the case of a 32 year old male presenting the classic features of Erythema Chronicum Migrans. Significant titles for Borrellia burgdorferi were then obtained. After an antibiotic triai with tetracycline a good response was obtained, with a quick disappearance of ali skin lesions. ln two months time new secondary skin lesions of Lyme disease, together with a bilateral and intense peri-orb...