4 documents found, page 1 of 1
Chitosan Nanoparticles: Shedding Light on Immunotoxicity and Hemocompatibility
Jesus, Sandra; Marques, Ana Patrícia; Duarte, Alana; Soares, Edna; Costa, João Panão da; Colaço, Mariana; Schmutz, Mélanie; Som, ClaudiaNanoparticles (NPs) assumed an important role in the area of drug delivery. Despite the number of studies including NPs are growing over the last years, their side effects on the immune system are often ignored or omitted. One of the most studied polymers in the nano based drug delivery system field is chitosan (Chit). In the scientific literature, although the physicochemical properties [molecular weight (MW) ...
How the Lack of Chitosan Characterization Precludes Implementation of the Safe-...
Marques, Cíntia; Som, Claudia; Schmutz, Mélanie; Borges, Olga; Borchard, GerritEfficacy and safety of nanomedicines based on polymeric (bio)materials will benefit from a rational implementation of a Safe-by-Design (SbD) approach throughout their development. In order to achieve this goal, however, a standardization of preparation and characterization methods and their accurate reporting is needed. Focusing on the example of chitosan, a biopolymer derived from chitin and frequently used in...
Editorial: Polymeric Nano-Biomaterials for Medical Applications: Advancements i...
Borchard, Gerrit; Som, Claudia; Zinn, Manfred; Ostafe, Vasile; Borges, Olga; Perale, Giuseppe; Wick, PeterHorizon 2020 framework program of the European Union, ProSafe Joint Transnational Call 2016, and from the CTI (1.1.2018 Innosuisse) under grant agreement number 19267.1 PFNM-NM.
Hazard Assessment of Polymeric Nanobiomaterials for Drug Delivery: What Can We ...
Jesus, Sandra; Schmutz, Mélanie; Som, Claudia; Borchard, Gerrit; Wick, Peter; Borges, OlgaThe physicochemical properties of nanobiomaterials, such as their small size and high surface area ratio, make them attractive, novel drug-carriers, with increased cellular interaction and increased permeation through several biological barriers. However, these same properties hinder any extrapolation of knowledge from the toxicity of their raw material. Though, as suggested by the Safe-by-Design (SbD) concept,...