30 documents found, page 1 of 3
How does the Alzheimer’s disease brain respond to optomechanical stimuli?: a na...
Monteiro, Francisca Machado; Oliveira, Sofia; Gasik, Michael; Sousa, Nuno; Sotiropoulos, I.; Silva, Filipe Samuel; Carvalho, Óscar Samuel NovaisAlzheimer's disease (AD) is a neurodegenerative condition with enormous social and economic impact at a global scale. Given the inefficacy of the pharmacological treatments developed so far in decelerating/blocking AD pathology, the study and development of so-called alternative (i.e., non-pharmacological) and non-invasive therapies has become one of the major focuses of biomedical research on AD in recent year...
Multi‑mechanical waves against Alzheimer’s disease pathology: a systematic review
Monteiro, Francisca Machado; Sotiropoulos, I.; Carvalho, Óscar Samuel Novais; Sousa, Nuno; Silva, Filipe SamuelAlzheimer’s disease (AD) is the most common cause of dementia, affecting approximately 40 million people worldwide. The ineffectiveness of the available pharmacological treatments against AD has fostered researchers to focus on alternative strategies to overcome this challenge. Mechanical vibrations delivered in different stimulation modes have been associated with marked improvements in cognitive and physical ...
Nucleus accumbens medium spiny neurons subtypes signal both reward and aversion
Soares-Cunha, Carina; Vasconcelos, Nivaldo António Portela; Coimbra, Bárbara; Domingues, Ana Verónica; Silva, Joana M.; Loureiro-Campos, EduardoDeficits in decoding rewarding (and aversive) signals are present in several neuropsychiatric conditions such as depression and addiction, emphasising the importance of studying the underlying neural circuits in detail. One of the key regions of the reward circuit is the nucleus accumbens (NAc). The classical view on the field postulates that NAc dopamine receptor D1-expressing medium spiny neurons (D1-MSNs) co...
Neuroplasticity-related correlates of environmental enrichment combined with ph...
Kokras, N.; Sotiropoulos, I.; Besinis, D.; Tzouveka, E. L.; Almeida, O. F. X.; Sousa, Nuno; Dalla, C.Environmental enrichment (EE), comprising positive physical (exercise) and cognitive stimuli, influences neuronal structure and usually improves brain function. The promise of EE as a preventative strategy against neuropsychiatric disease is especially high during early postnatal development when the brain is still amenable to reorganization. Despite the fact that male and female brains differ in terms of conne...
MORPhA Scale: behavioral and electroencephalographic validation of a rodent ane...
Esteves, Madalena; Almeida, António M.; Silva, Joana Margarida Gonçalves Mota; Moreira, Pedro Miguel Silva; Carvalho, Emanuel; Pêgo, José M.Background: Laboratory practice commonly implies rodent anesthesia. Such is instrumental not only for animal welfare, but also for standardized assessment of new anesthetics. New method: We developed and validated a grading system for a temporal follow-up of anesthesia. The Minho Objective Rodent Phenotypical Anesthesia (MORPhA) scale was tested in mice (C57BL/6 J) and rats (WistarHan) anesthetized with ketamin...
Chronic stress triggers divergent dendritic alterations in immature neurons of ...
Dioli, Chrysoula; Patrício, Patrícia; Sousa, Nuno; Kokras, Nikolaos; Dalla, Christina; Guerreiro, Sara; Santos-Silva, Miguel A.; Rego, Ana CristinaChronic stress, a suggested precipitant of brain pathologies, such as depression and Alzheimer's disease, is known to impact on brain plasticity by causing neuronal remodeling as well as neurogenesis suppression in the adult hippocampus. Although many studies show that stressful conditions reduce the number of newborn neurons in the adult dentate gyrus (DG), little is known about whether and how stress impacts ...
Dysregulation of autophagy and stress granule-related proteins in stress-driven...
Silva, Joana Margarida Gonçalves Mota; Rodrigues, Sara; Marques, Maria Belém Sousa Sampaio; Gomes, Patrícia; Carvalho, Andreia Alexandra NevesImbalance of neuronal proteostasis associated with misfolding and aggregation of Tau protein is a common neurodegenerative feature in Alzheimer's disease (AD) and other Tauopathies. Consistent with suggestions that lifetime stress may be an important AD precipitating factor, we previously reported that environmental stress and high glucocorticoid (GC) levels induce accumulation of aggregated Tau; however, the m...
Activated PPARγ Abrogates Misprocessing of Amyloid Precursor Protein, Tau Misso...
Moosecker, Susanne; Gomes, Patrícia; Dioli, Chrysoula; Yu, Shuang; Sotiropoulos, I.; Almeida, Osborne F. X.Type 2 diabetes increases the risk for dementia, including Alzheimer's disease (AD). Pioglitazone (Pio), a pharmacological agonist of the peroxisome proliferator-activated receptor γ (PPARγ), improves insulin sensitivity and has been suggested to have potential in the management of AD symptoms, albeit through mostly unknown mechanisms. We here investigated the potential of Pio to counter synaptic malfunction an...
Adrenoceptor-stimulated inflammatory response in stress-induced serum amyloid A...
Konstandi, Maria; Sotiropoulos, I.; Matsubara, Tsutomu; Malliou, Foteini; Katsogridaki, Alexandra; Andriopoulou, Christina E.; Gonzalez, Frank J.Rationale Stressful life events are suggested to contribute to the development of various pathologies, such as cardiovascular disorders, whose etiopathogenesis is highly associated with elevated levels of serum amyloid A (SAA) proteins. SAA synthesis inthe liver isregulated bya complex network ofcytokines actingindependently orinconcert withvarious hormones/stimulants including the stress-activated sympathetic ...
Endolysosomal degradation of Tau and its role in glucocorticoid-driven hippocam...
Vaz-Silva, João; Gomes, Patrícia; Jin, Qi; Zhu, Mei; Zhuravleva, Viktoriya; Quintremil, Sebastian; Meira, Torcato Duarte Novo; Silva, JoanaEmerging studies implicate Tau as an essential mediator of neuronal atrophy and cognitive impairment in Alzheimer's disease (AD), yet the factors that precipitate Tau dysfunction in AD are poorly understood. Chronic environmental stress and elevated glucocorticoids (GC), the major stress hormones, are associated with increased risk of AD and have been shown to trigger intracellular Tau accumulation and downstre...