5 documents found, page 1 of 1
In vitro optimization of photobiomodulation and ultrasound stimulation protocol...
Monteiro, Francisca; Oliveira, Sofia; Marques, Carlos; Papadimitriou, Georgia; Silva, Joana M.; Padrão, Jorge; Sotiropoulos, Ioannis; Catarino, SusanaThe effectiveness of transcranial photobiomodulation (tPBM) and ultrasound stimulation (tUS) to mitigate different neuropathological mechanisms and stimulate neuroprotective responses has been vastly demonstrated in preclinical disease models. However, the translation into clinics is still suboptimal, revealing the need for more solid basic research to ascertain the most effective stimulation parameters to modu...
Assessing the influence of ultrasound stimulation parameters in neuronal-like c...
Monteiro, Francisca; Oliveira, Sofia; Catarino, Susana Oliveira; Sotiropoulos, Ioannis; Carvalho, Óscar Samuel Novais; Silva, Filipe S.Alzheimer’s disease (AD) is a neurodegenerative disorder that represents the most common cause of dementia, but recent efforts to develop effective pharmacological treatments have been disappointing. However, non-drug solutions have been proposed to block disease progression and alleviate clinical symptoms, demonstrating promising results. Transcranial ultrasound stimulation is at the forefront of alternative t...
Chronic stress triggers divergent dendritic alterations in immature neurons of ...
Dioli, Chrysoula; Patrício, Patrícia; Sousa, Nuno; Kokras, Nikolaos; Dalla, Christina; Guerreiro, Sara; Santos-Silva, Miguel A.; Rego, Ana CristinaChronic stress, a suggested precipitant of brain pathologies, such as depression and Alzheimer's disease, is known to impact on brain plasticity by causing neuronal remodeling as well as neurogenesis suppression in the adult hippocampus. Although many studies show that stressful conditions reduce the number of newborn neurons in the adult dentate gyrus (DG), little is known about whether and how stress impacts ...
Tau protein is essential for stress-induced brain pathology
Lopes, Sofia; Silva, João Vaz; Pinto, Vítor; Dalla, Christina; Kokras, N.; Bedenk, Benedikt; Mack, Natalie; Czisch, Michael; Almeida, Osborne F. X.Exposure to chronic stress is frequently accompanied by cognitive and affective disorders in association with neurostructural adaptations. Chronic stress was previously shown to trigger Alzheimer's-like neuropathology, which is characterized by Tau hyper-phosphorylation and missorting into dendritic spines followed by memory deficits. Here, we demonstrate that stress-driven hippocampal deficits in wild-type mic...
Absence of Tau triggers age-dependent sciatic nerve morphofunctional deficits a...
Lopes, Sofia Oliveira; Lopes, André Teixeira; Pinto, Vítor Manuel Silva; Guimarães, Marco Rafael; Sardinha, Vanessa Alexandra Morais; Silva, Sara DuarteDementia is the cardinal feature of Alzheimer's disease (AD), yet the clinical symptoms of this disorder also include a marked loss of motor function. Tau abnormal hyperphosphorylation and malfunction are well-established key events in AD neuropathology but the impact of the loss of normal Tau function in neuronal degeneration and subsequent behavioral deficits is still debated. While Tau reduction has been inc...