3 documents found, page 1 of 1
Clinicopathologic predictors of renal outcomes in light chain cast nephropathy:...
Royal, V; Leung, N; Troyanov, S; Nasr, Sh; Écotière, L; LeBlanc, R; Adam, BA; Angioi, A; Alexander, MP; Asunis, AM; Barreca, A; Bianco, PC; Cohen, CLight chain cast nephropathy (LCCN) in multiple myeloma often leads to severe and poorly reversible acute kidney injury. Severe renal impairment influences the allocation of chemotherapy and its tolerability; it also affects patient survival. Whether renal biopsy findings add to the clinical assessment in predicting renal and patient outcomes in LCCN is uncertain. We retrospectively reviewed clinical presentati...
Mercapturate Pathway in the Tubulocentric Perspective of Diabetic Kidney Disease
Gonçalves-Dias, C; Morello, J; Correia, MJ; Coelho, N; Antunes, A; Macedo, MP; Monteiro, E; Soto, K, et al.BACKGROUND: The recent growing evidence that the proximal tubule underlies the early pathogenesis of diabetic kidney disease (DKD) is unveiling novel and promising perspectives. This pathophysiological concept links tubulointerstitial oxidative stress, inflammation, hypoxia, and fibrosis with the progression of DKD. In this new angle for DKD, the prevailing molecular mechanisms on proximal tubular cells emerge ...
High resolution mass spectrometry-based methodologies for identification of Etr...
Godinho, A; Martins, I; Nunes, J; Charneira, C; Grilo, J; Silva, D; Pereira, S; Soto, K, et al.Drug bioactivation to reactive metabolites capable of covalent adduct formation with bionucleophiles is a major cause of drug-induced adverse reactions. Therefore, elucidation of reactive metabolites is essential to unravel the toxicity mechanisms induced by drugs and thereby identify patient subgroups at higher risk. Etravirine (ETR) was the first second-generation Non-Nucleoside Reverse Transcriptase Inhibito...