13 documents found, page 1 of 2
CICTA2021 conference: advances in environmental toxicology in the face of emerg...
de Almeida, Eduardo Alves; Bebianno, Maria; Soto, Manuel; de Souza Abessa, Denis ModeloThe increasing levels of environmental pollutants in combination with global climate change has been a matter of great concern due to the negative impacts caused to natural environments. Studies on these topics are important to predict the environmental risks of pollutants, enabling decision-making towards the development of more efficient laws for the protection and preservation of natural environments against...
Antileishmanial activity and evaluation of the mechanism of action of strychnob...
Lage, Paula S.; Chávez-Fumagalli, Miguel A.; Mesquita, Juliana T.; Mata, Laís M.; Fernandes, Simone O. A.; Cardoso, Valbert N.; Soto, ManuelThe present study aimed to investigate the in vitro antileishmanial activity of strychnobiflavone flavonoid against Leishmania infantum, as well as its mechanism of action, and evaluate the ex vivo biodistribution profile of the flavonoid in naive BALB/c mice. The antileishmanial activity (IC50 value) of strychnobiflavone against stationary promastigote and amastigote-like stages of the parasites was of 5.4 and...
Antileishmanial activity and mechanism of action from a purified fraction of Zi...
Duarte, Mariana C.; Tavares, Grasiele S.V.; Valadares, Diogo G.; Lage, Daniela P.; Ribeiro, Tatiana G.; Lage, Letícia M.R.; Rodrigues, Marcella R.In recent years, considerable attention has been given to identify new antileishmanial products derived from medicinal plants, although, to date, no new effective compound has been recently applied to treat leishmaniasis. In the present study, the antileishmanial activity of a water extract from Zingiber officinalis Roscoe (ginger) was investigated and a purified fraction, named F10, was identified as responsib...
Sensitive and specific serodiagnosis of Leishmania infantum infection in dogs u...
Chávez Fumagalli, Miguel Angel; Martins, Vívian Tamietti; Testasicca, Miriam Conceição de Souza; Lage, Daniela Pagliara; Costa, Lourena EmanueleIn Brazil, the percentage of infected dogs living in areas where canine visceral leishmaniasis (CVL) is endemic ranges from 10 to 62%; however, the prevalence of infection in dogs is probably higher than figures reported from serological studies. In addition, problems with the occurrence of false-positive or false-negative results in the serodiagnosis of CVL have been reported. The present work analyzed the pot...
PLGA nanoparticles loaded with KMP-11 stimulate innate immunity and induce the ...
Santos, Diego M.; Carneiro, Marcia W.; Moura, Tatiana Rodrigues de; Soto, Manuel; Luz, Nívea Farias; Prates, Deboraci Brito; Barral, Aldina Maria PradoTexto completo: acesso restrito. p. 985–995; Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-04-29T14:11:17Z No. of bitstreams: 1 1-s2.0-S1549963413001755-main.pdf: 1378587 bytes, checksum: 7f7ed57efe858a0fe0a69d986cc9e5a5 (MD5); Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2014-09-09T14:49:36Z (GMT) No. of bitstreams: 1 1-s2.0-S1549963413001755-main.pdf: 1378587 bytes, ...
Towards a more precise serological diagnosis of human Tegumentary Leishmaniasis...
Souza, Ana Paula Almeida de; Soto, Manuel; Costa, Jackson M. L.; Boaventura, Viviane Sampaio; Oliveira, Camila Indiani de; Cristal, Juqueline Rochap. 1-6; Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-06-05T14:23:47Z No. of bitstreams: 1 journal.pone.0066110.pdf: 2195240 bytes, checksum: 984373ca555cc12b6642a1a82c251d56 (MD5); Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2014-10-10T15:15:48Z (GMT) No. of bitstreams: 1 journal.pone.0066110.pdf: 2195240 bytes, checksum: 984373ca555cc12b6642a1a82c251d56 (MD5); Made ...
Characterization of the immune response to Leishmania infantum recombinant anti...
Carvalho, Lucas Pedreira de; Soto, Manuel; Jerônimo, Selma; Dondji, Blaise; Bacellar, Maria Olívia Amado Ramos; Luz, Viviane; Orge, Glória OrgeTexto completo: acesso restrito. p. 7–12; Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-01-14T15:22:53Z No. of bitstreams: 1 Lucas Pedreira de Carvalho.pdf: 114743 bytes, checksum: dfbcf3fe3bbc3654b7c18cab2903f62d (MD5); Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-01-20T15:45:48Z (GMT) No. of bitstreams: 1 Lucas Pedreira de Carvalho.pdf: 114743 bytes, check...
Immunodominant Antigens of Leishmania chagasi Associated with Protection agains...
Abanades, Daniel R.; Arruda, Leonardo V.; Arruda, Elaine S.; Pinto, Jose Roberto A. S. [UNESP]; Palma, Mario Sergio [UNESP]; Aquino, DorleneMade available in DSpace on 2013-08-28T14:12:57Z (GMT). No. of bitstreams: 1 WOS000305945300029.pdf: 1240407 bytes, checksum: bc56fc9ebe40b66c13462774bc35db0c (MD5); Made available in DSpace on 2013-09-30T18:47:01Z (GMT). No. of bitstreams: 2 WOS000305945300029.pdf: 1240407 bytes, checksum: bc56fc9ebe40b66c13462774bc35db0c (MD5) WOS000305945300029.pdf.txt: 43661 bytes, checksum: 804298e1e7b0cb63a86234b8020fa7cd...
Recombinant Leishmania Antigens for Serodiagnosis of Visceral Leishmaniasis
Passos, S.; Carvalho, Lain Carlos Pontes de; Orge, G.; Jerônimo, S. M.; Bezerra, G. F.; Soto, Manuel; Alonso, Carlos; Carvalho Filho, Edgar Marcelino deTexto completo: acesso restrito.p.1164–1167; Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-11-06T11:37:55Z No. of bitstreams: 1 S. Passos.pdf: 158985 bytes, checksum: 2d6533c7af71d5d8744a1e12387498e5 (MD5); Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-11-08T18:38:14Z (GMT) No. of bitstreams: 1 S. Passos.pdf: 158985 bytes, checksum: 2d6533c7af71d5d8744a1e123874...
Towards development of novel immunization strategies against leishmaniasis usin...
Santos, Diego Moura; Carneiro, Marcia Weber; Moura, Tatiana Rodrigues de; Fukutani, Kiyoshi Ferreira; Clarêncio, Jorge; Soto, Manuel; Espuelas, SocorroFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil; Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil; Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil; Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil; Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil; Universidad Autonom...