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Diagnóstico e Seguimento Laboratorial de Doentes com Mieloma Múltiplo
Pires, Ana Marta; Barreto, João Pedro; Caetano, Joana; Rego De Sousa, Maria José; Geraldes, Catarina; Fernandes, Bruno; Coucelo, MargaridaMultiple myeloma is a neoplasm of plasma cells that in most cases is associated with the secretion of monoclonal immunoglobulins and can involve multiple organs. Its timely diagnosis is essential to limit or avoid irreversible damage and dysfunction of target organs. Appropriate initial stratification of patients allows for optimization in the selection and sequence of therapy, as well as proper follow-up durin...
Multiple Myeloma Laboratory Diagnostics Made Simple
Pires, Ana Marta; Barreto, João Pedro; Caetano, Joana; Soares, Maria José; Geraldes, Catarina; Fernandes, Bruno; Coucelo, Margarida; Chacim, SérgioPublisher Copyright: © 2025 by the authors.; Multiple myeloma is a clonal plasma cell malignancy with a highly variable range of clinical manifestations. Over recent decades, substantial progress has been made in laboratory diagnostics, which has deepened our understanding of disease biology, improved risk stratification, and informed treatment strategies. In an era of transformation and innovation, conventiona...
Accumulation of organophosphorus pollutants in adipose tissue of obese women - ...
Sousa, Sara; Rede, Diana; Cruz Fernandes, Virgínia; Pestana, Diogo; Faria, Gil; Delerue-Matos, Cristina; Calhau, ConceiçãoFunding Information: S. Sousa is grateful to FCT and ESF (European Social Fund) through POCH ( Programa Operacional Capital Humano ) for the Ph.D. grant ( SFRH/BD/137516/2018 and COVID/BD/153231/2023 ). The authors thank the General Surgery Department of Hospital de São João (Porto, Portugal) for the human adipose tissue samples and to all patients that consent to participate. Funding Information: This work was...
Adipose tissue fatty acids as biomarkers for metabolic dysfunction in obese fem...
Sousa, Sara; Pestana, Diogo; Faria, Gil; Delerue-Matos, Cristina; Calhau, Conceição; Fernandes Domingues, ValentinaFunding Information: S. Sousa is grateful to FCT and European Social Fund through Programa Operacional Capital Humano for the Ph.D . grant ( SFRH/BD/137516/2018-COVID/BD/153231/2023 ). The authors thank the General Surgery Department of Hospital de São João (Porto, Portugal) and to all patients that consented to participate. Funding Information: This work was financially supported by Portuguese national funds t...
Assessment of synthetic musks, polychlorinated biphenyls and brominated flame r...
Sousa, Sara; Pestana, Diogo; Faria, Gil; Delerue-Matos, Cristina; Calhau, Conceição; Fernandes Domingues, ValentinaFunding Information: This work was financially supported by Portuguese national funds through projects UIDB/50006/2020 , UIDP/50006/2020 , and LA/P/0008/2020 , from the Fundação para a Ciência e a Tecnologia (FCT)/ Ministério da Ciência, Tecnologia e Ensino Superior (MCTES). Funding Information: S. Sousa is grateful to FCT and ESF (European Social Fund) through POCH (Programa Operacional Capital Humano) for the...
Organochlorine pesticides, brominated flame retardants, synthetic musks and pol...
Maia, Maria Luz; Sousa, Sara; Correia-Sá, Maria Luísa; Delerue-Matos, Cristina; Calhau, Conceição; Domingues, Valentina FernandesShrimps are widely distributed in coastal areas, estuaries and rivers. Although this shellfish is a good source of nutrients, it can also accumulate environmental contaminants, such as organochlorine pesticides (OCPs), brominated flame retardants (BFRs), synthetic musks (SMs) and polycyclic aromatic hydrocarbons (PAHs). Due to their bioaccumulative properties, these pollutants are endocrine disruptors. In this ...
A new zebrafish bone crush injury model
Sousa, Sara; Valerio, Fabio; Jacinto, AntonioWhile mammals have a limited capacity to repair bone fractures, zebrafish can completely regenerate amputated bony fin rays. Fin regeneration in teleosts has been studied after partial amputation of the caudal fin, which is not ideal to model human bone fractures because it involves substantial tissue removal, rather than local tissue injury. In this work, we have established a bone crush injury model in zebraf...
An amputation resets positional information to a proximal identity in the regen...
Azevedo, Ana Sofia; Sousa, Sara; Jacinto, Antonio; Saúde, LeonorWe thank Lara Carvalho and Fabio Valerio for excellent zebrafish husbandry, Andreia Pinto for histology and Antonio Temudo for imaging support. We are grateful to C. Certal and S. Pascoal for comments on the manuscript. A. S. A and S. S were supported by FCT fellowships (SFRH/BD/33179/2007 and SFER/BD/32952/2006). L. S. was supported by two FCT grants (PTDC/SAU-OBD/64628/2006 and PTDC/SAU-OBD/100202/2008) and A...
In Vivo Cell and Tissue Dynamics Underlying Zebrafish Fin Fold Regeneration
Mateus, Rita; Pereira, Telmo; Sousa, Sara; de Lima, Joana Esteves; Pascoal, Susana; Saúde, Leonor; Jacinto, AntonioBackground: Zebrafish (Danio rerio) has a remarkable capacity to regenerate many organs and tissues. During larval stages the fin fold allows the possibility of performing long time-lapse imaging making this system very appealing to study the relationships between tissue movements, cell migration and proliferation necessary for the regeneration process. Results: Through the combined use of transgenic fluorescen...