27 documents found, page 1 of 3
Escape rooms as an innovative language learning tool in higher education touris...
Pires, A.; Pais, S.; Sousa, A. E.We live in an ever-changing society. The educational context is no exception and requires a renewal of paradigms. Profound changes to the role and function of the professor and the students are particularly vital. Active, cooperative and participative learning methodologies must be privileged, breaking with magisterial education and the mere transmission of knowledge. The escape room is a game experience that c...
The use of digital technologies in the teaching of mathematics during the COVID...
Pais, S.; Hall, A.; Sousa, A. E.Mathematics is one of the school subjects where demotivation is a frequent concern. Relating mathematics with other areas usually draws students’ attention and increases their involvement in the classes. It is necessary to go beyond the traditional; the teacher must look for resources that make his classes flow, so that the students acquire or increase their interest in mathematics. After the generalized lockdo...
Gut disruption in HIV-2 infection despite reduced viremia
Fernandes, S. M.; Pires, A. R.; Ferreira, C.; Tendeiro, R.; Correia, L.; Paulo, S. E.; Victorino, R. M.; Sousa, A. E.HIV-2 infection is highly prevalent inWest Africa and has been increasingly observed in non-African countries, mostly associated with migratory populations [1]. It has a much more benign course and lower viremia than HIV-1 [2], though with similar clinical spectra. Half of the HIV-2 infected patients with less than 200 CD4+ T-cells/ml exhibit undetectable viremia, despite harbouring numbers of infected cells co...
Human regulatory T-cell development is dictated by Interleukin-2 and -15 expres...
Caramalho, I.; Nunes-Silva, V.; Pires, A. R.; Mota, C.; Pinto, A. I.; Nunes-Cabaço, H.; Foxall, R. B.; Sousa, A. E.Thymus-derived FOXP3-expressing regulatory T-cells (tTregs) are master orchestrators of physiological and pathological immune responses, thus constituting ideal targets for the treatment of autoimmunity. Despite their clinical importance, the developmental program governing their differentiation in the human thymus remains poorly understood. Here, we investigated the role of common gamma-chain cytokines in huma...
Long-term immune reconstitution of naive and memory t cell pools after haploide...
Azevedo, R. I.; Soares, M. V.; Albuquerque, A. S.; Tendeiro, R.; Soares, R. S.; Martins, M.; Ligeiro, D.; Victorino, R. M.; Lacerda, J. F.; Sousa, A. E.Haploidentical hematopoietic stem cell transplantation (HSCT) constitutes an important alternative for patients lacking a human leukocyte antigen (HLA)-matched donor. Although the use of haploidentical donors is increasingly common, the long-term impact of generating a donor-derived immune system in the context of an HLA-mismatched thymic environment remains poorly characterized. We performed an in-depth assess...
Monocyte and myeloid dendritic cell activation occurs throughout HIV type 2 inf...
Cavaleiro, R.; Tendeiro, R.; Foxall, R. B.; Soares, R. S.; Baptista, A. P.; Gomes, P.; Valadas, Emília; Victorino, R. M.; Sousa, A. E.Monocytes and myeloid dendritic cells (mDCs) are important orchestrators of innate and human immunodeficiency virus (HIV)-specific immune responses and of the generalized inflammation that characterizes AIDS progression. To our knowledge, we are the first to investigate monocyte and mDC imbalances in HIV type 2 (HIV-2)-positive patients, who typically feature reduced viremia and slow disease progression despite...
Repairing thymic function
Nunes-Cabaço, H.; Sousa, A. E.Purpose of review: Maintenance of T-cell function and modulation of tolerance are critical issues in organ transplantation. The thymus is the primary organ for T-cell generation, and a preserved thymic function is essential for a self-tolerant diverse T-cell repertoire. Transplant procedures and related immunosuppressive drugs may hinder thymic integrity and function. We review here the recent advances in under...
Preserved CD4 T-cell telomere length during long-lasting HIV-2 infection --Manu...
Tendeiro, R.; Albuquerque, A. S.; Foxall, Russell B.; Cavaleiro, R.; Soares, R. S.; Baptista, A. P.; Soares, M. V.; Gomes, P.; Sousa, A. E.HIV-2 infection features a much slower course than HIV-1 infection, often asymptomatic for over 20 years, without antiretroviral therapy (ART). Nevertheless, CD4 T cells progressively decline, in direct correlation with immune activation and cell cycling. We report, for the first time, preserved telomere length within naive and memory CD4 subsets in prolonged HIV-2 infection despite the increased CD4 turnover.
Memory B-cell depletion is a feature of HIV-2 infection even in the absence of ...
Tendeiro, R.; Fernandes, S.; Foxall, R. B.; Marcelino, J. M.; Taveira, N.; Soares, R. S.; Baptista, A. P.; Cavaleiro, R.; Gomes, P.; Victorino, R. M.Objective: Memory B-cell loss has long been recognized as an important contributor to HIV immunodeficiency. HIV-2 infection, which is characterized by a slow rate of progression to AIDS and reduced to undetectable viremia, provides a unique model to investigate B-cell disturbances. Design and methods: B-cell subsets were evaluated in 38 HIV-2-infected individuals, along with markers of T-cell activation and ser...
Monocyte activation is a feature of common variable immunodeficiency irrespecti...
Barbosa, R. R.; Silva, S. P.; Silva, S. L.; Tendeiro, R.; Melo, A. C.; Pedro, E.; Barbosa, M. P.; Santos, M. C.; Victorino, R. M.; Sousa, A. E.Common variable immunodeficiency disorders (CVID), the most frequent cause of symptomatic primary immunodeficiency, are defined by impaired antibody production. Notwithstanding, T cell activation and granulomatous manifestations represent the main causes of CVID morbidity even in patients receiving immunoglobulin (Ig) G replacement therapy. Additionally, gut pathology is a frequent feature of CVID. In this stud...