2 documents found, page 1 of 1
Mannosylated glycans impair normal T-cell development by reprogramming commitme...
Vicente, MM; Alves, I; Fernandes, Â; Dias, AM; Santos-Pereira, B; Pérez-Anton, E; Santos, S; Yang, T; Correia, A; Münster-Kühnel, A; Almeida, ARMT-cell development ensures the formation of diverse repertoires of T-cell receptors (TCRs) that recognize a variety of antigens. Glycosylation is a major posttranslational modification present in virtually all cells, including T-lymphocytes, that regulates activity/functions. Although these structures are known to be involved in TCR-selection in DP thymocytes, it is unclear how glycans regulate other thymic dev...
The Dysfunctional Immune System in Common Variable Immunodeficiency Increases t...
Gullo, I; Costa, C; Silva, SL; Ferreira, C; Motta, A; Silva, SP; Ferreira, RD; Rosmaninho, P; Faria, E; Costa, JTd; Câmara, R; Gonçalves, GGastric carcinoma (GC) represents the most common cause of death in patients with common variable immunodeficiency (CVID). However, a limited number of cases have been characterised so far. In this study, we analysed the clinical features, bacterial/viral infections, detailed morphology and immune microenvironment of nine CVID patients with GC. The study of the immune microenvironment included automated digital...