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Late Onset Neuromyelitis Optica Spectrum Disorders (LONMOSD) from a Nationwide ...

Introduction: Several neuroimmunological disorders have distinct phenotypes according to the age of onset, as in multiple sclerosis or myasthenia gravis. It is also described that late onset NMOSD (LONMOSD) has a different phenotype. Objective: To describe the clinical/demographic characteristics of the LONMOSD and distinguish them from those with early onset (EONMOSD). Methods: From a nationwide Portuguese NMO...

Neuromyelitis Optica Spectrum Disorders: a Nationwide Portuguese Clinical Epide...

Introduction: Neuromyelitis optica spectrum disorder (NMOSD) is a rare disorder in which astrocyte damage and/or demyelination often cause severe neurological deficits. Objective: To identify Portuguese patients with NMOSD and assess their epidemiological/clinical characteristics. Methods: This was a nationwide multicenter study. Twenty-four Portuguese adult and 3 neuropediatric centers following NMOSD patients...

Neuromyelitis optica spectrum disorders: A nationwide Portuguese clinical epide...

Introduction: Neuromyelitis optica spectrum disorder (NMOSD) is a rare disorder in which astrocyte damage and/or demyelination often cause severe neurological deficits. Objective: To identify Portuguese patients with NMOSD and assess their epidemiological/clinical characteristics. Methods: This was a nationwide multicenter study. Twenty-four Portuguese adult and 3 neuropediatric centers following NMOSD patients...

Literacia em saúde parental e a utilização dos serviços de urgência pediátrica

A literacia em saúde pode ser definida, entre outras, como o nível da capacidade dos indivíduos para obter, processar e perceber informação de saúde básica e os serviços necessários para realizar decisões apropriadas sobre a sua saúde. Neste sentido, o objetivo deste estudo é identificar qual a literacia em saúde dos pais e cuidadores das crianças utilizadoras dos serviços de urgência pediátrica (SUP). Para tal...

LAMA2 gene mutation update: Toward a more comprehensive picture of the laminin-...

Congenital muscular dystrophy type 1A (MDC1A) is one of the main subtypes of early-onset muscle disease, caused by disease-associated variants in the laminin-α2 (LAMA2) gene. MDC1A usually presents as a severe neonatal hypotonia and failure to thrive. Muscle weakness compromises normal motor development, leading to the inability to sit unsupported or to walk independently. The phenotype associated with LAMA2 de...

Progressive Multifocal Leucoencephalopathy Limited to the Posterior Fossa as Fi...

Brachial Plexus Cyst in a Patient with Multifocal Motor Neuropathy

Breast Cancer Presents With a Paraneoplastic Neurologic Syndrome

BACKGROUND: Paraneoplastic neurologic syndromes (PNS) pose quite an uncommon neurological complication, affecting less than 1% of patients with breast cancer. Nearly one third of these patients lack detectable onconeural antibodies (ONAs), and improvement in neurologic deficits with concomitant cancer treatments is achieved in less than 30% of cases. CASE PRESENTATION: A 42-year-old, premenopausal woman present...

Dual use of Diff-Quik-like stains for the simultaneous evaluation of human sper...

BACKGROUND: Sperm chromatin status and nuclear DNA damage can be detected using well-established assays. However, most techniques are time-consuming and/or involve elaborate protocols and equipment. We have recently developed a simple and fast method to monitor sperm chromatin status in field conditions using the Diff-Quik assay which is employed in fertility clinics to assess sperm morphology with standard bri...