31 documents found, page 1 of 4
Tributyltin at Nanomolar Levels Impairs Antioxidant Capacity and Alters the Exp...
Rato, Luís; Silva, Branca M.; Sousa, Ana C. A.Objective: Obesogens are environmental pollutants promoting weight gain and metabolic disturbances. Among them, tributyltin (TBT) is a prototypical obesogen with well-documented detrimental effects on male reproductive health. Within the testes, Sertoli cells (SCs) are essential in supporting spermatogenesis and are considered sensitive targets of reproductive toxicity. This study aimed to evaluate whether TBT ...
White Tea Intake Mitigates SIRT1 Suppression in Prediabetes Skeletal Muscle: A ...
Fernandes, Bruno; Penha, A.; Capitão, Ana; Sousa, Ana C. A.; Silva, Branca M.; Rato, LuísObjective: Type 2 diabetes mellitus (T2DM) impairs skeletal muscle function, reducing metabolic flexibility and mitochondrial efficiency while increasing oxidative stress due to excess reactive oxygen species (ROS) and weak antioxidant defenses. Sirtuin 1 (SIRT1) and Sirtuin 3 (SIRT3), NAD⁺-dependent deacetylases, support mitochondrial health and activate ROS-detoxifying enzymes. We hypothesized that prediabete...
Tributyltin-Induced Disruption of Acetylation-Related Proteins and Epigenetic R...
Rato, Luís; Silva, Branca M.; Sousa, Ana C. A.Objective: Acetylation-related proteins like CREB-binding protein (CBP), general control non-depressible 5 (GCN5), and P300/CBP-associated factor (PCAF) are critical for chromatin remodeling and transcriptional regulation, particularly affecting the expression of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α). This study examines how exposure to the environmental obesogen tributyl...
Tackling water contamination by oncologic drugs: supported ionic liquids as sus...
Francisco, Rafael; Monteiro, Bruna; Santos, Maria J.; Silva, Francisca A. e; Venâncio, Cátia; Neves, Márcia C.; Lopes, Isabel; Sousa, Ana C. A.Due to the increasing incidence of cancer, the consumption of highly toxic oncological drugs is continuously growing. Given the current lack of efficient technologies to remove/treat these toxic drugs in wastewater treatment plants, the environmental quality is compromised, and aquatic organisms are at risk. To address this critical environmental burden, a new strategy based on supported ionic liquids (SILs) fo...
Multi-target analysis of cytostatics in hospital effluents over a 9-month period
Gouveia, Teresa I. A.; Silva, Adrián M. T.; Freire, Mara G.; Sousa, Ana C. A.; Alves, Arminda; Santos, Mónica S. F.The consumption of cytostatics, pharmaceuticals prescribed in chemotherapy, is increasing every year and worldwide, along with the incidence of cancer. The presence and the temporal evolution of cytostatics in wastewaters from a Portuguese hospital center was evaluated through a 9-month sampling campaign, comprising a total of one hundred and twenty-nine samples, collected from May 2019 to February 2020. Eleven...
High performance of ionic-liquid-based materials to remove insecticides
Francisco, Rafael; Almeida, Catarina; Sousa, Ana C. A.; Neves, Márcia C.; Freire, Mara G.Neonicotinoids are systemic insecticides commonly used for pest control in agriculture and veterinary applications. Due to their widespread use, neonicotinoid insecticides (neonics) are found in different environmental compartments, including water, soils, and biota, in which their high toxicity towards non-target organisms is a matter of great concern. Given their widespread use and high toxicity, the developm...
Development of Ionic-Liquid-based Devices for the Removal of Cytostatic Drugs f...
Francisco, Rafael; Freire, Mara G.; Sousa, Ana C. A.; Neves, Márcia C.Cytostatics are a common therapeutic option in the treatment of cancer and recovery of transplants. Nevertheless, these drugs are toxic, so their handling and elimination are sources of risk. With developments in cancer treatments, chemotherapy is now usually complemented and/or replaced by treatments in the home environment, where excretion of cytostatics, which occurs through urine or feces, can lead to conta...
Mercury levels in biological matrices from inhabitants of Estarreja, Portugal
Barros, Rafael; Pastorinho, M. Ramiro; Valente, João Vasco; Souto-Miranda, Sara; Marques, Alda; Valente, Carla; Taborda-Barata, Luís; Sousa, Ana C. A.Humans are exposed to mercury trough several pathways including the consumption of contaminated seafood and ingestion of contaminated house dust. We have previously demonstrated that mercury levels in house dust samples from Estarreja region are amongst the highest reported in Portugal. Here we report the levels of total mercury in different biological matrices from 88 adult individuals from Estarreja (age: 37-...
Environmental awareness for patients with COPD undergoing pulmonary rehabilitat...
Souto-Miranda, Sara; Gonçalves, Ana-Carolina; Valente, Carla; Freitas, Célia; Sousa, Ana C. A.; Marques, AldaChronic obstructive pulmonary disease (COPD) is impacted by exposure to environmental contaminants. Improving health literacy on this topic might help to optimize health outcomes. We aimed to design and deliver a health-education session about the impact of environmental contaminants on respiratory symptoms and explore participants' perceptions on such session. Patients with COPD were recruited from a pulmonary...
Valorization of expired energydrinks by designed and integrated ionic liquid-ba...
Dimitrijević, Aleksandra; Tavares, Ana P. M.; Almeida, Mafalda R.; Vraneš, Milan; Sousa, Ana C. A.; Cristóvão, Ana C.; Trtić-Petrović, TatjanaExpired energy drinks are rich in bioactive value-added compounds that can be recovered and reused in order to valorize food waste within a circular economy perspective. However, to accomplish such requirements, it is necessary to develop sustainable extraction and recovery processes, which must consist of decreasing the number of steps required or developing integrated strategies. In this work, novel aqueous b...