39 documents found, page 1 of 4
Tourism students' experience of emergency remote teaching due to COVID-19 pandemic
Pais, Sónia; Sousa, Ana E.The upsurge of the Covid-19 pandemic and the consequent lockdown led to school closure globally. Across the globe, students have been away from schools and their teachers. To cope up with this educational emergency, in Portugal all levels of education suspended face-to-face classes and were replaced by online activities. Within this context, the teacher involved in this study sought to adapt the activities and ...
Serum IL‐22 binding protein as a marker for atopic dermatitis activity and resp...
Varandas, Claudia; Santos, Maria Conceição; Neto, Marta; Sousa, Ana E.; Lopes, Anabela; Silva, SusanaWe investigated here the interleukin-22 (IL-22)/IL-22 Binding Protein (IL-22BP) axis in Atopic Dermatitis (AD) and its modulation upon treatment with Dupilumab, and our findings support its relevance in the clinical management of severe AD.
Phenotype of BTK‐lacking myeloid cells during prolonged COVID‐19 and upon conva...
Gomes, André; Farias, Guilherme B.; Trombetta, Amelia Chiara; Godinho-Santos, Ana; Parreira, Inês; Gonçalves, Hélder Diogo; Lessa Simões, MarianaXLA patient with 7-month course of COVID-19 with persistent plasma SARS-CoV-2 load revealed a sustained non-inflammatory profile of myeloid cells in association with contained severity of disease, arguing in favor of the use of BTK inhibitors in SARS-COV-2 infection.
Matrix Metalloproteinase-9 levels are associated with brain lesion and persiste...
de Sousa, Diana Aguiar; Pereira Santos, Maria Conceição; Serra-Caetano, Ana; Lucas Neto, Lia; Sousa, Ana Luísa; Gabriel, Denis; Correia, ManuelBackground: Elucidating mechanisms of brain damage in cerebral venous thrombosis (CVT) would be instrumental to develop targeted therapies and improve prognosis prediction. Matrix metalloproteinase-9 (MMP-9), a gelatinase that degrades major components of the basal lamina, has been associated to blood-brain barrier disruption. We aimed to assess, in patients with CVT, the temporal change in serum concentrations...
SARS‐CoV2 pneumonia recovery is linked to expansion of innate lymphoid cells ty...
Gomes, André; Farias, Guilherme B.; Dias Silva, Manuel; Laia, Joel; Trombetta, Amelia Chiara; Godinho-Santos, Ana; Rosmaninho, Pedro; Santos, Diana F.Accelerate lung repair in SARS-CoV-2 pneumonia is essential for pandemic handling. Innate lymphoid cells (ILCs) are likely players, given their role in mucosal protection and tissue homeostasis. We studied ILC subpopulations at two time points in a cohort of patients admitted in the hospital due to SARS-CoV-2 infection. COVID-19 patients with moderate/severe respiratory failure featured profound depletion of ci...
Dissection of the pre-germinal center B-cell maturation pathway in common varia...
del Pino-Molina, Lucía; López-Granados, Eduardo; Lecrevisse, Quentin; Torres Canizales, Juan; Pérez-Andrés, Martín; Blanco, Elena; Wentink, MarjoleinIntroduction: Common Variable Immunodeficiency (CVID) is characterized by defective antibody production and hypogammaglobulinemia. Flow cytometry immunophenotyping of blood lymphocytes has become of great relevance for the diagnosis and classification of CVID, due to an impaired differentiation of mature post-germinal-center (GC) class-switched memory B-cells (MBC) and severely decreased plasmablast/plasma cell...
Acute HIV-1 and SARS-CoV-2 infections Share Slan+ Monocyte Depletion - evidence...
Farias, Guilherme B.; Badura, Robert; Conceição, Carolina M.; Gomes, André; Godinho-Santos, Ana; Laia, Joel; Rosmaninho, Pedro; Santos, DianaMonocytes are key modulators in acute viral infections, determining both inflammation and development of specific B- and T-cell responses. Recently, these cells were shown to be associated to different SARS-CoV-2 infection outcome. However, their role in acute HIV-1 infection remains unclear. We had the opportunity to evaluate the mononuclear cell compartment in an early hyper-acute HIV-1 patient in comparison ...
Blood biomarkers associated with inflammation predict poor prognosis in cerebra...
de Sousa, Diana Aguiar; Pereira Santos, M. C.; Serra-Caetano, Ana; Lucas Neto, Lia; Sousa, A. L.; Gabriel, D.; Correia, M.; Gil-Gouveia, RaquelBackground and purpose: Experimental studies suggest inflammation can contribute to blood barrier disruption and brain injury in cerebral venous thrombosis (CVT). We aimed to determine whether blood biomarkers of inflammation were associated with the evolution of brain lesions, persistent venous occlusion or functional outcome in patients with CVT. Methods: Pathophysiology of Venous Infarction-Prediction of Inf...
Expanding the nude SCID/CID phenotype associated with FOXN1 homozygous, compoun...
Giardino, Giuliana; Sharapova, Svetlana O.; Ciznar, Peter; Dhalla, Fatima; Maragliano, Luca; Radha Rama Devi, Akella; Islamoglu, CandanHuman nude SCID is a rare autosomal recessive inborn error of immunity (IEI) characterized by congenital athymia, alopecia, and nail dystrophy. Few cases have been reported to date. However, the recent introduction of newborn screening for IEIs and high-throughput sequencing has led to the identification of novel and atypical cases. Moreover, immunological alterations have been recently described in patients ca...
Severe COVID-19 recovery is associated with timely acquisition of a myeloid cel...
Trombetta, Amelia Chiara; Farias, Guilherme B.; Gomes, André; Godinho-Santos, Ana; Rosmaninho, Pedro; Conceição, Carolina M.; Laia, JoelAfter more than one year since the COVID-19 outbreak, patients with severe disease still constitute the bottleneck of the pandemic management. Aberrant inflammatory responses, ranging from cytokine storm to immune-suppression, were described in COVID-19 and no treatment was demonstrated to change the prognosis significantly. Therefore, there is an urgent need for understanding the underlying pathogenic mechanis...