7 documents found, page 1 of 1
ATG9A regulates the dissociation of recycling endosomes from microtubules to fo...
Vale-Costa, Sílvia; Etibor, Temitope Akhigbe; Brás, Daniela; Sousa, Ana Laura; Ferreira, Mariana; Martins, Gabriel G.; Mello, Victor HugoAU It is:now Pleaseconfirmthatallheadinglevelsarerepresentedcorrectly established that many viruses that threaten public health : establish condensates via phase transitions to complete their lifecycles, and knowledge on such processes may offer new strategies for antiviral therapy. In the case of influenza A virus (IAV), liquid condensates known as viral inclusions, concentrate the 8 distinct viral ribonucleop...
ATG9A facilitates the biogenesis of influenza A virus liquid condensates near t...
Vale-Costa, Sílvia; Etibor, Temitope Akghibe; Brás, Daniela; Sousa, Ana Laura; Amorim, Maria JoãoMany viruses that threaten public health establish condensates via phase transitions to complete their lifecycles, and knowledge on such processes is key for the design of new antivirals. In the case of influenza A virus, liquid condensates known as viral inclusions are sites dedicated to the assembly of its 8-partite RNA genome. Liquid viral inclusions emerge near the endoplasmic reticulum (ER) exit sites, but...
Is the proteome of bronchoalveolar lavage extracellular vesicles a marker of ad...
Carvalho, Ana Sofia; Moraes, Maria Carolina Strano; Hyun Na, Chan; Fierro-Monti, Ivo; Henriques, Andreia; Zahedi, Sara; Bodo, CristianAcellular bronchoalveolar lavage (BAL) proteomics can partially separate lung cancer from non-lung cancer patients based on principal component analysis and multivariate analysis. Furthermore, the variance in the proteomics data sets is correlated mainly with lung cancer status and, to a lesser extent, smoking status and gender. Despite these advances BAL small and large extracellular vehicles (EVs) proteomes r...
PLK4 is a microtubule-associated protein that self-assembles promoting de novo ...
Montenegro Gouveia, Susana; Zitouni, Sihem; Kong, Dong; Duarte, Paulo; Ferreira Gomes, Beatriz; Sousa, Ana Laura; Tranfield, Erin M.; Hyman, AnthonyThe centrosome is an important microtubule-organising centre (MTOC) in animal cells. It consists of two barrel-shaped structures, the centrioles, surrounded by the pericentriolar material (PCM), which nucleates microtubules. Centrosomes can form close to an existing structure (canonical duplication) or de novo How centrosomes form de novo is not known. The master driver of centrosome biogenesis, PLK4, is critic...
Influenza A virus ribonucleoproteins form liquid organelles at endoplasmic reti...
Alenquer, Marta; Vale-Costa, Sílvia; Etibor, Temitope Akhigbe; Ferreira, Filipe; Sousa, Ana Laura; Amorim, Maria JoãoInfluenza A virus has an eight-partite RNA genome that during viral assembly forms a complex containing one copy of each RNA. Genome assembly is a selective process driven by RNA-RNA interactions and is hypothesized to lead to discrete punctate structures scattered through the cytosol. Here, we show that contrary to the accepted view, formation of these structures precedes RNA-RNA interactions among distinct vi...
PLK4 is a microtubule-associated protein that self assembles promoting de novo ...
Gouveia, Susana Montenegro; Zitouni, Sihem; Kong, Dong; Duarte, Paulo; Gomes, Beatriz Ferreira; Sousa, Ana Laura; Tranfield, Erin M.; Hyman, AnthonyThe centrosome is an important microtubule-organizing centre (MTOC) in animal cells. It consists of two barrel-shaped structures, the centrioles, surrounded by the pericentriolar material (PCM), which nucleates microtubules. Centrosomes can form close to an existing structure (canonical duplication) or de novo How centrosomes form de novo is not known. The master driver of centrosome biogenesis, PLK4, is critic...
Influenza A virus ribonucleoproteins modulate host recycling by competing with ...
Vale-Costa, Sílvia; Alenquer, Marta; Sousa, Ana Laura; Kellen, Bárbara; Ramalho, José; Tranfield, Erin M.; Amorim, Maria JoãoInfluenza A virus assembly is an unclear process, whereby individual virion components form an infectious particle. The segmented nature of the influenza A genome imposes a problem to assembly because it requires packaging of eight distinct RNA particles (vRNPs). It also allows genome mixing from distinct parental strains, events associated with influenza pandemic outbreaks. It is important to public health to ...