6 documents found, page 1 of 1

Improving aptamer performance with nucleic acid mimics: de novo and post-SELEX ...

Aptamers are structural single-stranded oligonucleotides generated in vitro to bind to a specific target molecule. Aptamers versatility can be enhanced with nucleic acid mimics (NAMs) during or after a selection process, also known as systematic evolution of ligands by exponential enrichment (SELEX). We address advantages and limitations of the technologies used to generate NAM aptamers, especially the applicab...

Modelling aptamers with nucleic acid mimics (NAM): from sequence to three-dimen...

Aptamers are single-stranded oligonucleotides, formerly evolved by Systematic Evolution of Ligands by EXponential enrichment (SELEX), that fold into functional three-dimensional structures. Such conformation is crucial for aptamers ability to bind to a target with high affinity and specificity. Unnatural nucleotides have been used to develop nucleic acid mimic (NAM) aptamers with increased performance, such as ...

Adaptação cultural e linguística da Kaiser Physical Activity Survey (KPAS) para...

Introdução: A Kaiser Physical Activity Survey (KPAS) é um instrumento fiável e razoavelmente preciso para estimar a atividade física entre gestantes. Objetivo: Traduzir para Português Europeu e adaptar para a cultura portuguesa a versão oficial do instrumento KPAS. Métodos: A equivalência semântica da versão portuguesa desta medida foi obtida pela tradução, retroversão, consecução de uma versão de consenso e an...

Matrix Metalloproteinase-9 levels are associated with brain lesion and persiste...

Background: Elucidating mechanisms of brain damage in cerebral venous thrombosis (CVT) would be instrumental to develop targeted therapies and improve prognosis prediction. Matrix metalloproteinase-9 (MMP-9), a gelatinase that degrades major components of the basal lamina, has been associated to blood-brain barrier disruption. We aimed to assess, in patients with CVT, the temporal change in serum concentrations...

Benefits of the clinical pilates program in lower back pain in young handball p...

Does the Interplay Between Aging and Neuroinflammation Modulate Alzheimer's Dis...

Alzheimer's disease (AD) is a chronic neurodegenerative disorder and is the most common cause of dementia worldwide. Cumulative data suggests that neuroinflammation plays a prominent and early role in AD, and there is compelling data from different research groups of age-associated dysregulation of the neuroimmune system. From the clinical point of view, despite clinical resemblance and neuropathological findin...