63 documents found, page 1 of 7

Aspartic acid unveils as antibiofilm agent and tobramycin adjuvant against muco...

Antibiotics are central to managing airway infections in cystic fibrosis (CF), yet current treatments often fail due to the presence of Pseudomonas aeruginosa biofilms, settling down the need for seeking therapies targeting biofilms. This study aimed to investigate the antibiofilm activity of aspartic acid and its potential as an adjuvant to tobramycin against P. aeruginosa biofilms formed by mucoid and small c...

Aqueous extracts of Moringa oleifera and Cinnamomum cassia as promising sources...

Bacterial biofilms formed by Staphylococcus aureus and Pseudomonas aeruginosa pose significant challenges in treating cystic fibrosis (CF) airway infections due to their resistance to antibiotics. New therapeutic approaches are urgently needed to treat these chronic infections. This study aimed to investigate the antibiofilm potential of various plant extracts, specifically targeting mucoid and small colony var...

Acolhimento na Escola Superior de Saúde de Viseu : Roteiro do Programa de Mento...

Aptamer-based therapy for fighting biofilm-associated infections

Biofilms are key players in the pathogenesis of most of chronic infections associated with host tissue or fluids and indwelling medical devices. These chronic infections are hard to be treated due to the increased biofilms tolerance towards antibiotics in comparison to planktonic (or free living) cells. Despite the advanced understanding of their formation and physiology, biofilms continue to be a challenge and...

Challenges with drug efficacy prediction of in vitro models of biofilms infecti...

[Excerpt] Cystic fibrosis (CF) is a genetic disorder caused by a defect in the CF transmembrane conductance regulator gene, characterized by the accumulation of thick, sticky, and acidified sputum in the lungs. This abnormal buildup of sputum, rich in nutrients, and the defective mucociliary clearance render CF patients vulnerable to both acute and chronic bacterial infections of the airways. These infections l...

Mechanistic insights into succinic acid as an adjuvant for ciprofloxacin in tre...

Pseudomonas aeruginosa is a major cause of chronic respiratory infections in patients with cystic fibrosis (CF), with biofilm formation contributing to its persistence and antibiotic resistance. This study aimed to gain insights into the mechanistic action of succinic acid as a ciprofloxacin adjuvant against clinically relevant CF isolates, including small colony variants and mucoid strains, and a ciprofloxacin...

Selection of specific aptamers for mucoid Pseudomonas aeruginosa biofilms devel...

Chronic infections are one of the main contributors for decline of the lung function, respiratory failure and premature death of cystic fibrosis (CF) patients. Pseudomonas aeruginosa is an opportunistic pathogen that commonly infects CF lungs and recognized as the main cause of chronic infections due to its ability of biofilm formation. Being associated with concerning mortality rates, a rapid detection and ide...

Evolving biofilm inhibition and eradication in clinical settings through plant-...

Background After almost 100 years since evidence of biofilm mode of growth and decades of intensive investigation about their formation, regulatory pathways and mechanisms of antimicrobial tolerance, nowadays there are still no therapeutic solutions to eradicate bacterial biofilms and their biomedical related issues. Purpose This review intends to provide a comprehensive summary of the recent and most relevant ...

The impact of immunomodulation on host response and microbiota evolution

The interplay between gut microbiota and the host is important for immunity development, colonization resistance and host metabolism. Antibiotic use disrupts host-microbiota interactions, potentially decreasing the colonization resistance conferred by the gut microbiota. Lipopolysaccharide (LPS), an endotoxin present in Gram-negative bacteria, induces potent acute systemic inflammation. Nevertheless, it has als...

Prevenção de infeções crónicas de Pseudomonas aeruginosa em fibrose quística: o...

As infeções crónicas nas vias respiratórias por Pseudomonas aeruginosa são a principal causa de morbilidade e mortalidade em pacientes com fibrose quística (FQ). Assim, esta bactéria é o principal alvo terapêutico em FQ e, apesar dos avanços dos esquemas terapêuticos, as infeções continuam a persistir devido maioritariamente à formação de biofilmes. Consequentemente, é crucial o desenvolvimento de novas estraté...