9 documents found, page 1 of 1
Exploring the potential protective effect of probiotics in obesity-induced colo...
Viana, Rejane; Rocha, Ana C.; Sousa, André P.; Ferreira, Diogo; Fernandes, Rúben; Almeida, Cátia; Pais, Patrick J.; Baylina, Pilar; Pereira, Ana CláudiaColorectal cancer (CRC) is the third most common cancer diagnosed today and the third leading cause of death among cancer types. CRC is one of the gastrointestinal tumors with obesity as the main extrinsic risk factor, since, according to authors, the meta-inflammation sustained by the excess adipose tissue can provide abundant circulating lipids, as well as hormones and metabolites crucial to tumor development...
Exploring the anti-cancer properties of pomegranate peel aqueous extract
Luís, Carla; Sousa, André P.; Costa, Raquel; Maduro, Ana T.; Pais, Patrick J.; Sá, Sara; Gestoso, Álvaro; Fernandes, Flávia; Jerónimo, ElianaThe objective of this work is to evaluate the influence of pomegranate peel extract (PPE) in the behavior of breast cell lines (epithelial and tumor type) and related oxidative metabolism. Fruitbased functional foods have been the target of increasing scientific research for their physiological and pathophysiological properties. Pomegranate (Punica granatum) is a suitable example with both prophylactic and medi...
Moving towards personalized medicine—The broad use of aptamers for targeted the...
Sousa, André P.; Rocha, Ana C.; Almeida, Cátia; Carneiro, Mariana C. C. G.; Pais, Patrick P.; Viana, Rejane; Fernandes, Rúben; Barata, PedroAptamers are short, single-stranded oligonucleotides synthesized in vitro from a randomized oligonucleotide library against a specific target. These molecules are capable of binding to a wide range of biological targets with high specificity and affinity. They present great advantages over antibodies with potential applications in research, diagnosis, and therapeutics. Specifically for tumors with late-stage id...
Moving towards personalized medicine - the broad use of aptamers for targeted t...
Sousa, André P.; Rocha, Ana C.; Almeida, Cátia; Carneiro, Mariana C. C. G.; Pais, Patrick P.; Viana, Rejane; Fernandes, Rúben Rodrigues; Barata, PedroAptamers are short, single-stranded oligonucleotides synthesized in vitro from a randomized oligonucleotide library against a specific target. These molecules are capable of binding to a wide range of biological targets with high specificity and affinity. They present great advantages over antibodies with potential applications in research, diagnosis, and therapeutics. Specifically for tumors with late-stage id...
Metabolic disruption of gold nanospheres, nanostars and nanorods in human metas...
Soares, Sílvia; Pereira, Cláudia; Sousa, André P.; Oliveira, Ana Catarina; Sales, Maria Goreti; Correa-Duarte, Miguel A.; Guerreiro, Susana G.Nanomaterials offer a broad spectrum of applications in biomedicine. The shapes of gold nanoparticles could modulate tumor cell behavior. Spherical (AuNPsp), stars (AuNPst) and rods (AuNPr) shapes of polyethylene glycol coated-gold nanoparticles (AuNPs-PEG) were synthesized. Metabolic activity, cellular proliferation, and reactive oxygen species (ROS) were measured and the impact of AuNPs-PEG in metabolic enzym...
Cannabidiol and terpene formulation reducing SARS-CoV-2 infectivity tackling a ...
Santos, Susana; Barata, Pedro; Charmier, Adilia; Lehmann, Inês; Rodrigues, Suzilaine; Melosini, Matteo M.; Pais, Patrick J.; Sousa, André P.In late 2019, COVID-19 emerged in Wuhan, China. Currently, it is an ongoing global health threat stressing the need for therapeutic compounds. Linking the virus life cycle and its interaction with cell receptors and internal cellular machinery is key to developing therapies based on the control of infectivity and inflammation. In this framework, we evaluate the combination of cannabidiol (CBD), as an anti-infla...
The impact of metabolic syndrome and type 2 diabetes Mellitus on prostate cancer
Sousa, André P.; Costa, Raquel; Alves, Marco G.; Soares, Raquel; Baylina, Pilar; Fernandes, RúbenProstate cancer (PCa) remains the second most common type of cancer in men worldwide in 2020. Despite its low death rate, the need for new therapies or prevention strategies is critical. The prostate carcinogenesis process is complex and multifactorial. PCa is caused by a variety of mutations and carcinogenic events that constitutes the disease’s multifactorial focus, capable of not only remodeling cellular act...
Enhanced 3T3-L1 differentiation into adipocytes by pioglitazone pharmacological...
Teixeira, Catarina; Sousa, André P.; Santos, Inês; Rocha, Ana Catarina; Alencastre, Inês; Pereira, Ana Cláudia; Martins-Mendes, Daniela; Barata, PedroDespite the primary function of pioglitazone in antidiabetic treatment, this drug is a potent inducer of PPAR-γ, a crucial receptor that is involved in adipocyte differentiation. In this work, we propose an optimized methodology to enhance the differentiation of 3T3-L1 fibroblasts into adipocytes. This process is crucial for adipocyte secretome release, which is fundamental for understanding the molecular mecha...
Which role plays 2-Hydroxybutyric acid on Insulin resistance?
Sousa, André P.; Cunha, Diogo M.; Franco, Carolina; Teixeira, Catarina; Gojon, Frantz; Baylina, Pilar; Fernandes, RúbenType 2 Diabetes Mellitus (T2D) is defined as a chronic condition caused by beta cell loss and/or dysfunction and insulin resistance (IR). The discovering of novel biomarkers capable of identifying T2D and other metabolic disorders associated with IR in a timely and accurate way is critical. In this review, 2-hydroxybutyric acid (2HB) is presented as that upheaval biomarker with an unexplored potential ahead. Du...