3 documents found, page 1 of 1
Customizing 3D structures of vertically aligned carbon nanotubes to direct neur...
Nascimento, Luís; Fernandes, Cristiana; Silva, Ricardo M.; Semitela, Ângela; Sousa, Bárbara M. de; Marques, Paula A. A. P.; Vieira, Sandra I.Neural tissue-related illnesses have a high incidence and prevalence in society. Despite intensive research efforts to enhance the regeneration of neural cells into functional tissue, effective treatments are still unavailable. Here, a novel therapeutic approach based on vertically aligned carbon nanotube forests (VA-CNT forests) and periodic VA-CNT micropillars produced by thermal chemical vapor deposition is ...
Bioengineered hierarchical bonelike compartmentalized microconstructs using nan...
Bjørge, Isabel M.; Sousa, Bárbara M. de; Patrício, Sónia G.; Silva, Ana Sofia; Nogueira, Liebert P.; Santos, Lúcia F.; Vieira, Sandra I.Fabrication of vascularized large-scale constructs for regenerative medicine remains elusive since most strategies rely solely on cell self-organization or overly control cell positioning, failing to address nutrient diffusion limitations. We propose a modular and hierarchical tissue-engineering strategy to produce bonelike tissues carrying signals to promote prevascularization. In these 3D systems, disc-shaped...
KIF4A: unravelling a potential spinal cord repair gene using regenerative perip...
Sousa, Bárbara M. de; Correia, Patrícia D.; Chato-Astraín, Jesús; Silva, Raquel; Müller, Hans Werner; Carriel, Víctor; Bosse, Frank; Vieira, Sandra I.Spinal cord injury (SCI) seriously impairs functions below injury level and has no effective treatment yet. Central neurons may be stimulated to regenerate in more permissive environments. Our mining for transcriptomic data from manipulated rodent SCI models presenting improved motor functions, retrieved sets of common differentially expressed genes (DEGs) involved in recovery. Amongst the up-regulated DEGs was...