4 documents found, page 1 of 1
Purification, biochemical characterization, and amino acid sequence of a novel ...
Carneiro, Rômulo Farias; Torres, Renato Cézar Farias; Chaves, Renata Pinheiro; Vasconcelos, Mayron Alves de; Sousa, Bruno Lopes deA new lectin from Aplysia dactylomela eggs (ADEL) was isolated by affinity chromatography on HClactivated Sepharose™ media. Hemagglutination caused by ADEL was inhibited by several galactosides, mainly galacturonic acid (Ka = 6.05 × 106 M−1 ). The primary structure of ADEL consists of 217 residues, including 11 halfcystines involved in five intrachain and one interchain disulfide bond, resulting in a molecular ...
Explaining RANKL inhibition by OPG through quantum biochemistry computations an...
Sousa, Bruno Lopes de; Barroso Neto, Ito Liberato; Oliveira, Evanildo Ferreira; Fonseca, Emerson Alberto da; Lima Neto, Pedro de; Ladeira, Luiz OrlandoOsteoporosis is a degenerative disease associated with excessive bone resorption, a natural process performed by osteoclasts. In turn, osteoclast maturation is critically regulated by the receptor activator of nuclear factor kB ligand (RANKL), its signalling receptor (RANK), and its decoy receptor osteoprotegerin (OPG). The critical role of the protein triad, RANK–RANKL–OPG, in osteoclastogenesis has made their...
Caracterização estrutural das formas silvestre e recombinante de uma lectina de...
Sousa, Bruno Lopes deSOUSA, Bruno Lopes de.Caracterização estrutural das formas silvestre e recombinante de uma lectina de sementes de Vatairea macrocarpa Benth e análise das suas bases moleculares de ligação ao antígeno Tn. 2014. 119 f. Tese (Doutorado em Bioquímica)-Universidade Federal do Ceará, Fortaleza-CE, 2014.; Lectins are a very diverse class of proteins able to bind specific sugar structures reversibly and with high speci...
Caracterização parcial de uma pro-lectina funcional de sementes de Dioclea gran...
Sousa, Bruno Lopes deSOUSA, B. L. Caracterização parcial de uma pro-lectina funcional de sementes de Dioclea grandiflora Benth expressa em Escherichia coli. 2010. 93 f. Dissertação (Mestrado em Bioquímica) - Centro de Ciências, Universidade Federal do Ceará, Fortaleza, 2010.; The pro-lectin from Dioclea grandiflora presented active when expressed in recombinant (r-pro-DGL) in the cytoplasm of the model prokaryotic Escherichia coli....