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Rapid and long-lasting antidepressant-like effects of ketamine and their relati...
Viana, Glauce S. B.; Vale, Eduardo Mulato do; Araujo, A. R. A. de; Coelho, N. C.; Andrade, S. M.; Costa, R. O. da; Aquino, Pedro Everson Alexandre deKetamine (KET) is an N-methyl-D-aspartate (NMDA) antagonist with rapid and long-lasting antidepressant effects, but how the drug shows its sustained effects is still a matter of controversy. The objectives were to evaluate the mechanisms for KET rapid (30 min) and long-lasting (15 and 30 days after) antidepressant effects in mice. A single dose of KET (2, 5, or 10 mg/kg, po) was administered to male Swiss mice ...
Date: 2021
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Origin: Oasisbr