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Behavioral and neurochemical effects of alpha-lipoic acid in the model of Parki...

Araújo, Dayane Pessoa de; Sousa, Caren Nádia Soares De; Araújo, Paulo Victor Pontes; Menezes, Carlos Eduardo de Souza

This study aimed to investigate behavioral and neurochemical effects of -lipoic acid (100mg/kg or 200mg/kg) alone or associated with L-DOPA using an animal model of Parkinson’s disease induced by stereotaxic injection of 6-hydroxydopamine (6-OHDA) in rat striatum. Motor behavior was assessed by monitoring body rotations induced by apomorphine, open field test and cylinder test. Oxidative stress was accessed by ...

Date: 2013   |   Origin: Oasisbr
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