3 documents found, page 1 of 1
Envolvimento de vias oxidativas, inflamatórias e neurotróficas no efeito antide...
Sousa, Caren Nádia Soares deDepression is a severe and disabling psychiatric disorder that affects people of all socioeconomic classes, ethnicities and ages. Oxidative stress, neuroinflammation and the deficit of neurotrophic factors have been highlighted as justification for the symptoms and therapeutic failure in depression. Based on assumption that carvedilol (CVD) present antioxidant and anti-inflammatory properties, was proposed to e...
Antidepressants, antimicrobials or both? Gut microbiota dysbiosis in depression...
Macedo, Danielle; Chaves Filho, Adriano José Maia; Sousa, Caren Nádia Soares de; Quevedo, João; Barichello, Tatiana; Nobre Júnior, Hélio VitorianoObjectives The first drug repurposed for the treatment of depression was the tuberculostatic iproniazid. At present, drugs belonging to new classes of antidepressants still have antimicrobial effects. Dysbiosis of gut microbiota was implicated in the development or exacerbation of mental disorders, such as major depressive disorder (MDD). Based on the current interest in the gut-brain axis, the focus of this na...
Efeitos comportamentais e neuroquímicos de ácido alfa-lipóico e desvenlafaxina ...
Sousa, Caren Nádia Soares deDepression is a serious and disabling psychiatric disorder that affects people of all socioeconomic classes, ethnicities and ages. Recent studies have suggested a possible involvement of oxidative stress in the pathogenesis of depression and substances with antioxidant potential may be used to treat this disorder. Based on this assumption, the present study investigated the behavioral and neurochemical effects ...