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Pre-clinical assessment of Roflumilast therapy in a thoracic model of spinal co...
Sousa, Carla S.; Lima, Rui Augusto Ribeiro; Cibrão, Jorge R.; Gomes, Eduardo D.; Fernandes, Luís S.; Pinho, Tiffany Santos; Silva, DeolindaThe failure of axons to regenerate after a spinal cord injury (SCI) remains one of the greatest challenges in neuroscience. The initial mechanical trauma is followed by a secondary injury cascade, creating a hostile microenvironment, which not only is not permissive to regeneration but also leads to further damage. One of the most promising approaches for promoting axonal regeneration is to maintain the levels ...
Date: 2023
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Origin: RepositóriUM - Universidade do Minho