5 documents found, page 1 of 1
Silk sericin/chitosan supramolecular multilayered thin films as sustainable cyt...
Rosas, Miguel; Sousa, Cristiana F. V.; Pereira, Ana; Amaral, Adérito J. R.; Pesqueira, Tamagno; Patrício, Sónia G.; Fateixa, SaraSilk sericin (SS) has been widely discarded as a waste by the silk textile industry during the degumming process to obtain fibroin. However, in the past decade, an in-depth understanding of its properties and functions turned it into a high added-value biomaterial for biomedical applications. Herein, we report the molecular design and development of sustainable supramolecular multilayered nanobiomaterials encom...
Marine-origin polysaccharides-based free-standing multilayered membranes as sus...
Sousa, Cristiana F. V.; Monteiro, Luís P. G.; Rodrigues, João M. M.; Borges, João; Mano, João F.The layer-by-layer (LbL) assembly technology has been widely used to functionalise surfaces and precisely engineer robust multilayered bioarchitectures with tunable structures, compositions, properties, and functions at the nanoscale by resorting to a myriad of building blocks exhibiting complementary interactions. Among them, marine-origin polysaccharides are a sustainable renewable resource for the fabricatio...
Supramolecular dendrimer-containing layer-by-layer nanoassemblies for bioapplic...
Sousa, Cristiana F. V.; Fernandez-Megia, Eduardo; Borges, João; Mano, João F.Dendrimers are powerful synthetic macromolecular architectures for a wide variety of bioapplications owing to their unique and superior features, including monodispersity, well-defined and highly branched architecture, multivalency, tunable size and shape, good water solubility, bioavailability, and precisely controllable size at the nanometer-scale. However, the cationic and higher generation dendrimers have g...
Customizable and Regioselective One-Pot N−H Functionalization of DNA Nucleobase...
Rocha, Djenisa H. A; Machado, Carmen M.; Sousa, Vera; Sousa, Cristiana F. V.; Silva, Vera L. M.; Silva, Artur M.; Borges, João; Mano, João F.DNA is one of the most exciting biomolecules in nature for developing supramolecular biofunctional nanoarchitectures owing to the highly specific and selective interactions between complementary Watson-Crick base pairing. Herein, simple and one-pot synthetic procedures have been implemented for producing a library of DNA nucleobase derivatives endowed with reactive functional groups for bioconjugation and cross...
Bioinstructive Layer-by-Layer-Coated Customizable 3D Printed Perfusable Microch...
Sousa, Cristiana F. V.; Saraiva, Catarina A.; Correia, Tiago R.; Pesqueira, Tamagno; Patrício, Sónia G.; Rial-Hermida, Maria Isabel; Borges, JoãoThe development of complex and large 3D vascularized tissue constructs remains the major goal of tissue engineering and regenerative medicine (TERM). To date, several strategies have been proposed to build functional and perfusable vascular networks in 3D tissue-engineered constructs to ensure the long-term cell survival and the functionality of the assembled tissues after implantation. However, none of them ha...