5 documents found, page 1 of 1
Non-canonical amino acids as building blocks for peptidomimetics: structure, fu...
Castro, Tarsila Gabriel; Melle-Franco, Manuel; Sousa, Cristina E. A.; Cavaco-Paulo, Artur; Marcos, João CarlosThis review provides a fresh overview of non-canonical amino acids and their applications in the design of peptidomimetics. Non-canonical amino acids appear widely distributed in nature and are known to enhance the stability of specific secondary structures and/or biological function. Contrary to the ubiquitous DNA-encoded amino acids, the structure and function of these residues are not fully understood. Here,...
Development of colorimetric cellulose-based test-strip for the rapid detection ...
Correia, Bárbara P.; Sousa, Mariana P.; Sousa, Cristina E. A.; Mateus, Daniela; Sebastião, Ana Isabel; Cruz, Maria Teresa; Matos, Ana MiguelGiven the pandemic situation, there is an urgent need for an accurate test to monitor antibodies anti-SARS-CoV-2, providing crucial epidemiological and clinical information to monitor the evolution of coronavirus disease in 2019 (COVID-19) and to stratify the immunized and asymptomatic population. Therefore, this paper describes a new cellulosebased test strip for rapid and cost-efective quantitative detection ...
Paper-based biosensors for COVID-19: a review of innovative tools for controlli...
Pinheiro, Tomás; Cardoso, A. Rita; Sousa, Cristina E. A.; Marques, Ana C.; Tavares, Ana P. M.; Matos, Ana Miguel; Cruz, Maria TeresaThe appearance and quick spread of the new severe acute respiratory syndrome coronavirus disease, COVID-19, brought major societal challenges. Importantly, suitable medical diagnosis procedures and smooth clinical management of the disease are an emergent need, which must be anchored on novel diagnostic methods and devices. Novel molecular diagnostic tools relying on nucleic acid amplification testing have emer...
(3S,4R)-3,4-Dihydroxy-N-alkyl-l-homoprolines: synthesis and computational mecha...
Freitas, David S.; Sousa, Cristina E. A.; Parente, Joana; Drogalim, Artem; Fortes, A. Gil; Cerqueira, Nuno M. F. S. A.; Rodríguez-Borges, José E.This is the first synthetic report of (3S,4R)-dihydroxy-N-alkyl-l-homoprolines described so far. 2,4-O-Benzylidene-d-erythrose was obtained from d-glucose with an improved yield, and then transformed into the title (3S,4R)-dihydroxy-N-alkyl-l-homoprolines, in a two-step strategy, with excellent overall yields. Hydrogenolysis of the benzyl group led to the NH congener. The synthesis of final products from 1,4-la...
Total Stereoselective Michael Addition of N- and S- Nucleophiles to a D-Erythro...
Rocha, Juliana F.; Freitas, David S.; Noro, Jennifer Martins; Silva Teixeira, Carla S.; Sousa, Cristina E. A.; Alves, Maria José ChãoThe synthesis of a 1,S-lactone 2,4-O-alkylidene-D-erythrose derivative was found to be a highly stereoselective template in Michael addition trough the reaction of a D-erythrosyl 1,5-lactone derivative with nitrogen and sulfur nucleophiles. The sulfur adducts formed are 1 (D-erythrose derivative):1 (nucleophile), and the nitrogen adducts are 1:2. Both were then treated under HCl to give 2,6-dideoxy-4-functional...