1 document found, page 1 of 1
Sort by
Issue Date
Side-effects of analgesic kyotorphin derivatives : advantages over clinical opi...
Ribeiro, Marta M. B.; Santos, Sónia Sá; Sousa, David S. C.; Oliveira, Margarida; Santos, Sara M.; Heras, Montserrat; Bardaji, Eduard; Tavares, IsauraThe adverse side-effects associated with opioid administration restrain their use as analgesic drugs and call for new solutions to treat pain. Two kyotorphin derivatives, kyotorphin-amide (KTP–NH2) and ibuprofen–KTP–NH2 (IbKTP–NH2) are promising alternatives to opioids: they trigger analgesia via an indirect opioid mechanism and are highly effective in several pain models following systemic delivery. In vivo si...
Date: 2013
|
Origin: Repositório da Universidade de Lisboa