Anterior cruciate ligament (ACL) injuries pose significant challenges, driving the need for innovative repair strategies. Tissue engineering (TE) has emerged as a promising field for ACL injuries. Wet spinning is a filament production technique that enables precise control over filament alignment, diameter, and porosity, making it suitable for developing new scaffolds for ACL injuries. This study develops fibro...
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Introduction: Several clinical trials have established the efficacy and safety of dupilumab for treating atopic dermatitis (AD). However, literature remains scarce in reporting the long-term effectiveness, safety, and drug survival of dupilumab in real-world settings. This study aimed to describe the latter outcomes of dupilumab in patients with AD. Methods: This Portuguese, multicentric, observational, retrosp...
Pathogen genome sequencing during epidemics enhances our ability to identify and understand suspected clusters and investigate their relationships. Here, we combine genomic and epidemiological data of the 2022 mpox outbreak to better understand early viral spread, diversification and transmission dynamics. By sequencing 52% of the confirmed cases in Portugal, we identified the mpox virus sublineages with the hi...
[Excerpt] Introduction Tendon and ligament injuries have a major impact on joint mobility and musculoskeletal performance. Current treatments frequently fall short of expectations, necessitating the development of artificial fibrous scaffolds that closely resemble native tissue. Wet polymeric nanofibers, particularly those based on poly(-caprolactone) (PCL), have shown promise in terms of biocompatibility, biod...
Late-onset pharyngeal perforation is a rare complication of anterior cervical spine osteosynthesis. Clinical presentation is variable and may led to serious complications. We present a 49-year-old male patient with a six-week history of throat pain and foreign body sensation. He had a previous documented odontoid fracture treated with osteosynthesis with an interf ragmentary screw performed 30 years ago. A scre...
Pathogen genome sequencing during epidemics enhances our ability to identify and understand suspected clusters and investigate their relationships. Here, we combine genomic and epidemiological data of the 2022 mpox outbreak to better understand early viral spread, diversification and transmission dynamics. By sequencing 52% of the confirmed cases in Portugal, we identified the mpox virus sublineages with the hi...
Giant cell tumors (GCTs) of the ischium are rare and often diagnosed at an advanced stage. In fact, there is no defined treatment algorithm to treat this lesion. We present two case reports of Campanacci's stage three ischiopubic GCT confirmed with biopsy. They were effectively treated with excision of the ischiopubic ramus, aggressive curettage, drilling, and phenolization at the margins. The surgery was perfo...